AB240103

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free

RabMAb
Recombinant
각 태그의 뜻

Be the first to review this product! 리뷰 제출

(0 출판물)

Rabbit Recombinant Monoclonal Somatostatin Receptor 1/SSTR1 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples.

대체 명칭 보기

Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SST1, SRIF-2, SSTR1

1 이미지

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free (AB240103)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free (AB240103)

Immunofluorescent analysis of 2936E cells labelling Somatostatin Receptor 1/SSTR1 with ab137083 at 1/250 dilution.

This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab137083).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

UMB7

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

제품 세부 정보

ab240103 is the carrier-free version of ab137083.

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar^® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar^® is a trademark of Fluidigm Canada Inc.

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Do Not Freeze

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Somatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.

Biological function summary

SSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.

Pathways

SSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.

SSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

See full target information SSTR1

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free

Immunocytochemistry/ Immunofluorescence - Anti-Somatostatin Receptor 1/SSTR1 antibody [UMB7] - BSA and Azide free (AB240103)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

Product promise