AB121759

Anti-SON/DBP5 antibody

Name: Anti-SON/DBP5 antibody
Brand: Abcam Limited
SKU: AB121759
Rating: 5 (1 reviews)

(1 리뷰)

(14 제품이 사용된 논문 )

Anti-SON/DBP5 antibody (ab121759) is a rabbit polyclonal antibody detecting SON/DBP5 in IHC-P. Suitable for Human.

대체 명칭 보기

C21orf50, DBP5, KIAA1019, NREBP, HSPC310, HSPC312, SON, Protein SON, Bax antagonist selected in saccharomyces 1, Negative regulatory element-binding protein, Protein DBP-5, SON3, BASS1, NRE-binding protein

5 이미지

Unknown

Immunocytochemistry - Anti-SON/DBP5 antibody (AB121759)

ab121759, at 4 μg/ml, staining SON/DBP5 (green) in PFA-fixed, Triton X-100 permbabilized U-251 MG cells, by Immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human prostate tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in glandular cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human small intestine tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong postiivty in nuclear speckles in glandular cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human tonsil tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in germinal center cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human cerebellum tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in Purkinje cells.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SON aa 1450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P18583

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.25-2 µg/mL", "ICC-species-notes": "<p></p>" } } }

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제품 세부 정보

What is this antibody validated in?
Anti-SON/DBP5 antibody (ab121759) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence : 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed : 27545680).

See full target information SON

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제품이 사용된 논문 (14)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 13: PubMed40900123

2025

DNA methylation insulates genic regions from CTCF loops near nuclear speckles.

Applications

Unspecified application

Species

Unspecified reactive species

Shelby A Roseman,Allison P Siegenfeld,Ceejay Lee,Nicholas Z Lue,Amanda L Waterbury,Brian B Liau

Nature communications 16:390 PubMed39755675

2025

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention.

Applications

Unspecified application

Species

Unspecified reactive species

Alexa B R McIntyre,Adrian Beat Tschan,Katrina Meyer,Severin Walser,Arpan Kumar Rai,Keisuke Fujita,Lucas Pelkmans

Nature cell biology 27:322-335 PubMed39747580

2025

Nuclear speckles regulate functional programs in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine A Alexander,Ruofan Yu,Nicolas Skuli,Nathan J Coffey,Son Nguyen,Christine L Faunce,Hua Huang,Ian P Dardani,Austin L Good,Joan Lim,Catherine Y Li,Nicholas Biddle,Eric F Joyce,Arjun Raj,Daniel Lee,Brian Keith,M Celeste Simon,Shelley L Berger

Communications biology 7:763 PubMed38914653

2024

Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Teng Hsiao,I-Hsin Liao,Bo-Kuan Wu,Hsueh-Ping Catherine Chu,Chia-Lung Hsieh

Journal of virology 98:e0190123 PubMed38629840

2024

Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells.

Applications

Unspecified application

Species

Unspecified reactive species

Juliette Bougon,Eileigh Kadijk,Lucie Gallot-Lavallee,Bruce A Curtis,Matthew Landers,John M Archibald,Denys A Khaperskyy

Cell stem cell 30:1658-1673.e10 PubMed38065069

2023

SON is an essential mA target for hematopoietic stem cell fate.

Applications

Unspecified application

Species

Unspecified reactive species

Hanzhi Luo,Mariela Cortés-López,Cyrus L Tam,Michael Xiao,Isaac Wakiro,Karen L Chu,Aspen Pierson,Mandy Chan,Kathryn Chang,Xuejing Yang,Daniel Fecko,Grace Han,Eun-Young Erin Ahn,Quaid D Morris,Dan A Landau,Michael G Kharas

Frontiers in cell and developmental biology 11:1217637 PubMed37484912

2023

Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts.

Applications

Unspecified application

Species

Unspecified reactive species

Peter Hoboth,Martin Sztacho,Alexander Quaas,Baki Akgül,Pavel Hozák

PloS one 17:e0274091 PubMed36201559

2022

Epithelial cell size dysregulation in human lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Clifford W Sandlin,Song Gu,Jun Xu,Charuhas Deshpande,Michael D Feldman,Matthew C Good

MethodsX 8:101372 PubMed34430268

2021

Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates.

Applications

Unspecified application

Species

Unspecified reactive species

Peter Hoboth,Ondřej Šebesta,Martin Sztacho,Enrique Castano,Pavel Hozák

Molecular cell 81:1666-1681.e6 PubMed33823140

2021

p53 mediates target gene association with nuclear speckles for amplified RNA expression.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine A Alexander,Allison Coté,Son C Nguyen,Liguo Zhang,Omid Gholamalamdari,Paula Agudelo-Garcia,Enrique Lin-Shiao,K M A Tanim,Joan Lim,Nicolas Biddle,Margaret C Dunagin,Charly R Good,Mariel R Mendoza,Shawn C Little,Andrew Belmont,Eric F Joyce,Arjun Raj,Shelley L Berger

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SON/DBP5 antibody

Immunocytochemistry - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

제품이 사용된 논문 (14)

Product promise