AB168619
Mouse Polyclonal SPOP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SPOP.
대체 명칭 보기
Speckle-type POZ protein, HIB homolog 1, Roadkill homolog 1, SPOP
1 이미지
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-SPOP antibody (AB168619)
Immunofluorescent analysis of HeLa cells labeling SPOP with ab168619 at 10 μg/ml.
대체품
보완 제품
![Flow Cytometry (Intracellular) - Anti-Cullin 3/CUL-3 antibody [EPR3196Y] (AB75851)](https://content.abcam.com/products/images/cullin-3-cul-3-antibody-epr3196y-ab75851--flow-cytometry-intracellular-img78786.jpg)
Primary Antibodies
AB111947
20ul selling size|RabMAb|Recombinant|Lab Essentials
![Immunocytochemistry/ Immunofluorescence - Anti-GST antibody [EPR4236] (AB111947)](https://content.abcam.com/products/images/gst-antibody-epr4236-ab111947--immunocytochemistry-immunofluorescence-img87661.jpg)
- 0
- 0
Primary Antibodies
AB267787
Anti-PTEN antibody [EPR22636-122]
BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTEN antibody [EPR22636-122] (AB267787)](https://content.abcam.com/products/images/pten-antibody-epr22636-122-ab267787--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img79627.jpg)
- 0
- 0
Reactivity 정보
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
특성 및 보관 정보
제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
제품 프로토콜
For this product, it's our understanding that no specific protocols are required. You can visit:
- Visit the General protocols
- Visit the Troubleshooting
타겟 정보
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (PubMed : 32109420). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation (PubMed : 36791496). Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (PubMed : 37622993). Facilitates the lysosome-dependent degradation of enterovirus EV71 protease 2A by inducing its 'Lys-48'-linked polyubiquitination, which ultimately restricts EV71 replication (PubMed : 37796126). Acts as an antiviral factor also against hepatitis B virus/HBV by promoting ubiquitination and subsequent degradation of HNF1A (PubMed : 38018242). In turn, inhibits HBV transcription and replication by preventing HNF1A stimulating activity of HBV preS1 promoter and enhancer II (PubMed : 38018242). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (By similarity).
제품이 사용된 논문 (4)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Clinical and experimental medicine 25:243 PubMed40640517
2025
SPOP-dependent destabilization of SYT12 in a GSK-3β-dependent manner in papillary thyroid cancer cells.
Applications
Unspecified application
Species
Unspecified reactive species
Shaocheng Zhou,Qidan Du,Limei Xu,Xiaohong Kang
OncoTargets and therapy 12:9239-9248 PubMed31819473
2019
SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway.
Applications
Unspecified application
Species
Unspecified reactive species
Yanxi Li,Qiubo Yu,Ruohan Li,Jing Luo,Dong Yuan,Jiao Song,Yixuan Sun,Tengfei Long,Zhu Yang
EBioMedicine 44:138-149 PubMed31105033
2019
APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP.
Applications
Unspecified application
Species
Unspecified reactive species
Huiyuan Gong,Fei Liu,Xiaoyu Liu,Shengping Min,Nan Wu,Xincheng Liu,Yueguang Liu,Sue Han,Yijie Zhang,Yuefang Zhang,Yudong Hu,Xuegang Liu,Xiaojing Wang
Cancer research 78:2886-2896 PubMed29572225
2018
Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma.
Applications
Unspecified application
Species
Unspecified reactive species
Remi Adelaiye-Ogala,Nur P Damayanti,Ashley R Orillion,Sreevani Arisa,Sreenivasulu Chintala,Mark A Titus,Chinghai Kao,Roberto Pili
Product promise
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