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AB317097

Anti-STAM antibody [HL1635]

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Rabbit Recombinant Monoclonal STAM1 antibody. Suitable for WB, ICC/IF and reacts with Transfected cell lysate, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STAM.

대체 명칭 보기

STAM1, STAM, Signal transducing adapter molecule 1, STAM-1

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-STAM antibody [HL1635] (AB317097)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-STAM antibody [HL1635] (AB317097)

ab317097 detects STAM protein at cytoplasm by immunofluorescent analysis.
Sample : HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green : STAM stained by ab317097 diluted at 1 : 500.
Blue : Fluoroshield with DAPI.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL1635

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human STAM.

Q92783

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보완 제품

Primary Antibodies

AB151545

Anti-STAM2 antibody [EPR8688]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-STAM2 antibody [EPR8688] (AB151545)

  • 0
  • 0
Primary Antibodies

AB11317

Anti-gamma Tubulin antibody - Centrosome Marker

Immunocytochemistry/ Immunofluorescence - Anti-gamma Tubulin antibody - Centrosome Marker (AB11317)

  • 4
  • 16
Primary Antibodies

AB155539

Anti-HGS antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-HGS antibody - C-terminal (AB155539)

  • 4
  • 3
Proteins & Peptides

AB159929

Recombinant Human STAM1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human STAM1 protein (GST tag N-Terminus) (AB159929)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/100000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" }, "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/100000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

STAM or Signal Transducing Adaptor Molecule is a protein involved in intracellular signaling pathways. It is also known by the alternate name STAM-1 and has a mass of approximately 55 kDa. STAM is expressed in various tissues with a significant presence in the immune and hematopoietic systems. Its mechanical role involves interacting with different cellular components to facilitate signal transduction. The protein mainly localizes to the cytoplasm and occasionally associates with membrane-bound organelles.
Biological function summary

STAM engages in processes that are essential for signal transduction and endosomal sorting. It works as part of a larger protein complex known as the ESCRT-0 complex which is important for regulating endocytosis and sorting of ubiquitinated membrane proteins. This complex includes other proteins such as Hrs and plays a role in the degradation of signaling receptors assisting in modulating cell signaling and maintaining cellular equilibrium.

Pathways

STAM is implicated in the endocytic and ubiquitin-proteasome systems. It interacts significantly with the endocytosis pathway participating in the sorting of endocytic vesicles. In this context STAM's function involves cooperation with proteins like Hrs in the ESCRT machinery which manages membrane receptor recycling and degradation. By controlling these pathways it modulates signal transduction and influences cell fate decisions.

STAM's dysfunction is linked to certain conditions including cancer and neurodegenerative diseases. In cancer aberrant STAM function can result in uncontrolled cellular proliferation as seen with its association with proteins such as c-MET a receptor tyrosine kinase. In neurodegenerative diseases malfunction of STAM can disrupt cellular homeostasis and protein degradation pathways contributing to neuronal cell death. Understanding STAM's interactions and pathways can provide insights into potential therapeutic targets for these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.. (Microbial infection) Plays an important role in Dengue virus entry.
See full target information STAM
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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