AB239518

Anti-Stanniocalcin 1/STC antibody [C5]

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(2 제품이 사용된 논문 )

Mouse Monoclonal Stanniocalcin 1/STC antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STC1 aa 1-250.

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Stanniocalcin 1/STC with ab239518 at 10 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

Supplier Data

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

All lanes:

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (ab239518) at 5 µg/mL

All lanes:

Recombinant human Stanniocalcin 1/STC protein

Predicted band size: 28 kDa

false

Supplier Data

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

All lanes:

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (ab239518) at 3 µg/mL

All lanes:

Pig testis tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG at 0.2 µg/mL

Predicted band size: 28 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2b

Light chain 타입

kappa

Carrier free

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STC1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P52823

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A/G

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 1 (STC1) is a glycoprotein hormone with a mass of about 56 kDa. Alternate names for this protein include STC and STC-1. It is expressed in various tissues such as the kidney brain and ovary. STC1 plays a significant mechanical role in the regulation of calcium and phosphate transport across cell membranes. It interacts with certain receptors on cell surfaces to modulate ion exchange contributing to the maintenance of mineral homeostasis.

Biological function summary

Stanniocalcin 1 regulates calcium and phosphate balance and performs roles in cellular metabolism and antioxidant defense. It acts independently not as part of a complex but sometimes affects cascades leading to oxidative stress responses. STC1 adjusts energy metabolism by managing reactive oxygen species thereby enhancing cell survival under stress conditions. Its signaling impacts energy balance and adaptive responses in metabolically active tissues.

Pathways

Despite its independent operation Stanniocalcin 1 is integrated into oxidative stress and inflammatory pathways. It is involved in the Akt/PKB signaling pathway which influences cell survival and stress response. STC1 intersects with other proteins like PTH (parathyroid hormone) within the calcium metabolism pathways affecting bone and renal function. Through these pathways it facilitates cellular adaptation to metabolic demands.

Researchers link Stanniocalcin 1 to osteoporosis and cancer. Its role in calcium homeostasis makes it relevant in osteoporosis where bone density and strength are compromised. In the context of cancer STC1's influence on cell survival and stress responses may contribute to tumorigenesis although its function can be protective or detrimental depending on the cellular environment. The interaction of STC1 with proteins like PTH highlights its involvement in bone-related pathologies and potential roles in cancer progression.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

See full target information STC1

대체 명칭 보기

STC, STC1, Stanniocalcin-1, STC-1

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of biochemical and molecular toxicology 36:e23025 PubMed35603999

2022

NF-κB-upregulated miR-155-5p promotes hepatocyte mitochondrial dysfunction to accelerate the development of nonalcoholic fatty liver disease through downregulation of STC1.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Shen,Hanghai Pan,Jinjing Ke,Fei Zhao

Frontiers in cell and developmental biology 9:731086 PubMed34722511

2021

Molecular and Clinical Significance of Stanniocalcin-1 Expression in Breast Cancer Through Promotion of Homologous Recombination-Mediated DNA Damage Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Hou,Jigan Cheng,ZeHua Dai,Na Wei,Huan Chen,Shu Wang,Min Dai,Leilei Li,Hua Wang,Qing Ni

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Stanniocalcin 1/STC antibody [C5]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

Western blot - Anti-Stanniocalcin 1/STC antibody [C5] (AB239518)

관련 conjugated 항체와 다양한 조성의 항체 (2)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (2)

Product promise