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AB243103

Anti-Staphylococcus Enterotoxin A antibody [SA01]

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Mouse Monoclonal ETXA antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus, Purified native protein - Staphylococcus aureus samples. Immunogen corresponding to Cell preparation containing Staphylococcus aureus protein.

대체 명칭 보기

Enterotoxin type A, SEA, entA

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

SA01

Isotype

IgG2a

Carrier free

No

Reacts with

Staphylococcus aureus

Applications

WB, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Reacts with enterotoxin A and B of Stapylococcus aureus. Reactivity with other types of the enterotoxins has not been tested.

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대체품

Primary Antibodies

AB15897

Anti-Staphylococcus Enterotoxin A antibody

  • 0
  • 0

보완 제품

Primary Antibodies

AB190465

Anti-entB antibody [3D10]

Functional Studies (Neut/Block) - Anti-entB antibody [3D10] (AB190465)

  • 0
  • 0
Primary Antibodies

AB190467

Anti-alpha-hemolysin antibody [8B7] - N-terminal

Western blot - Anti-alpha-hemolysin antibody [8B7] - N-terminal (AB190467)

  • 0
  • 0
Primary Antibodies

AB20920

Anti-Staphylococcus aureus antibody

Immunocytochemistry/ Immunofluorescence - Anti-Staphylococcus aureus antibody (AB20920)

  • 4
  • 8
Primary Antibodies

AB19483

Anti-Protein A antibody

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Purified native protein - Staphylococcus aureus": { "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Staphylococcus aureus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
Purification 관련 사항
Affinity purified with Protein A/G Mix.
보관 버퍼
pH: 6 - 8.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Staphylococcus Enterotoxin A (SEA) also known simply as Enterotoxin A is one of the key virulence factors produced by the bacterium Staphylococcus aureus. This protein is classified as an enterotoxin and has a molecular mass of approximately 27 kDa. SEA is endogenously expressed by Staphylococcus aureus and it is known to exert its effects in the human gastrointestinal tract by binding to major histocompatibility complex (MHC) class II molecules thereby activating T-cells.
Biological function summary

The function of SEA involves triggering a strong immune response through its role as a superantigen. Enterotoxins such as SEA can bypass the conventional antigen presentation pathway leading to massive cytokine release. This protein can provoke a large-scale activation of T-cells not through specific antigen binding but rather through cross-linking of MHC class II molecules and T-cell receptors. SEA does not typically form complexes with other proteins as its main mechanism of action relies on interaction with cell surface receptors.

Pathways

SEA integrates into the immune response pathway by inducing excessive cytokine production contributing to inflammation. It plays a notable role in the cytokine signaling pathway causing unregulated production of inflammatory cytokines. This interferes with normal immune system function leading to toxic shock syndrome in severe cases. SEA also has a connection with other enterotoxins produced by Staphylococcus aureus such as Enterotoxin B through its role in stimulating immune responses.

SEA is associated with food poisoning and toxic shock syndrome. Food poisoning arises from the ingestion of food contaminated with SEA leading to nausea vomiting and diarrhea. Toxic shock syndrome occurs when SEA enters the bloodstream causing systemic inflammation and acute symptoms. SEA has an indirect relationship with other staphylococcal toxins as they share similar pathways in disease progression including Enterotoxin B which also contributes to toxic shock syndrome.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules (PubMed : 12467569, PubMed : 2658055). In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells (PubMed : 23321986). Also causes the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death (Probable).
See full target information entA
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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