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AB227687

Anti-STAT5 antibody [SP283] - C-terminal

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(4 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal STAT5a antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications.

대체 명칭 보기

STAT5, STAT5A, Signal transducer and activator of transcription 5A

10 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human bladder transitional cell carcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human bladder transitional cell carcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human skin squamous cell carcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human colon adenocarcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human cervical squamous cell carcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human endometrial adenocarcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human bladder tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human ovarian adenocarcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human B-Cell lymphoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 antibody [SP283] - C-terminal (AB227687)

Formalin-fixed paraffin-embedded human colon adenocarcinoma tissue stained for STAT5 using ab227687 at 1/100 dilution in immunohistochemical analysis.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-STAT5 antibody [SP283] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

SP283

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB32364

Anti-STAT5 (phospho Y694) antibody [E208]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 (phospho Y694) antibody [E208] (AB32364)

  • 4
  • 11
Primary Antibodies

AB219607

Anti-STAT5 (phospho Y694) antibody [E208] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5 (phospho Y694) antibody [E208] - BSA and Azide free (AB219607)

  • 0
  • 0
Primary Antibodies

AB230670

Anti-STAT5 antibody [9F7]

Flow Cytometry (Intracellular) - Anti-STAT5 antibody [9F7] (AB230670)

  • 0
  • 0
Primary Antibodies

AB98338

Anti-STAT5 (phospho Y694) antibody

Immunocytochemistry/ Immunofluorescence - Anti-STAT5 (phospho Y694) antibody (AB98338)

  • 0
  • 0

보완 제품

Assay Kits

AB205714

STAT 5 A/B ELISA Kit

SimpleStep

Sandwich ELISA - STAT 5 A/B ELISA Kit (AB205714)

  • 5
  • 1
Primary Antibodies

AB277762

Anti-STAT5a (phospho Y694) antibody [6HCLC]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STAT5a (phospho Y694) antibody [6HCLC] (AB277762)

  • 0
  • 0
Primary Antibodies

AB215715

Anti-TGF beta 1 antibody [EPR21143]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-TGF beta 1 antibody [EPR21143] (AB215715)

  • 5
  • 7
Primary Antibodies

AB178941

Anti-STAT5b antibody [EPR16671]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-STAT5b antibody [EPR16671] (AB178941)

  • 5
  • 4
Primary Antibodies

AB40794

Anti-FAK antibody [EP695Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAK antibody [EP695Y] (AB40794)

  • 5
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p>Boil tissue section in EDTA buffer (Cat# DEBX-050), pH 8.0 for 10 minfollowed by cooling at room temperature for 20 min.</p><p>Incubate with ab227687 for 10 minutes at room temperature.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
Purification 관련 사항
Purified from TCS by protein A/G.
보관 버퍼
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Signal Transducer and Activator of Transcription 5 commonly known as STAT5 is a member of the STAT protein family. It weighs approximately 94 kDa. STAT5 usually exists in two closely related forms STAT5a and STAT5b with both playing similar roles but having slightly different activity. This protein is widely expressed found in cells like lymphocytes epithelial cells and endothelial cells indicating its importance in various tissues.
Biological function summary

STAT5 acts as a transcription factor that modulates gene expression by binding to specific DNA sequences. It often forms part of a larger complex when activated. This complex relocation to the nucleus triggers transcriptional activities essential for cell growth differentiation and survival. As it interacts with other proteins STAT5 plays an important role in cytokine signaling particularly in response to interleukins and growth hormones.

Pathways

STAT5 is important in the JAK-STAT signaling pathway. This pathway is activated by cytokines and growth factors leading to STAT5 phosphorylation and its subsequent translocation into the nucleus. The interaction with Janus kinases (JAKs) facilitates this process. STAT5 also plays a significant role in the MAPK pathway linking it to various cellular responses and functions.

STAT5 has a strong association with oncological conditions like leukemia and lymphomas. Aberrant activation or dysregulation of STAT5 can lead to uncontrolled cell proliferation and survival contributing to cancer. Furthermore STAT5 is linked with autoimmune diseases with its malfunction affecting immune response and leading to disorders. In these conditions proteins like BCL-XL often interact with STAT5 influencing cell survival pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Carries out a dual function : signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
See full target information STAT5A
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 15:441 PubMed38909034

2024

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Deng,Xinjun Lu,Xue Wang,Binyong Liang,Hongwei Xu,Doris Yang,Guofei Cui,Andrew Yonemura,Honor Paine,Yi Zhou,Yi Zhang,Maria Maddalena Simile,Francesco Urigo,Matthias Evert,Diego F Calvisi,Benjamin L Green,Xin Chen

Frontiers in immunology 11:1415 PubMed32733471

2020

Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition.

Applications

Unspecified application

Species

Unspecified reactive species

Yiming Li,Pan Zhai,Yawen Zheng,Jing Zhang,John A Kellum,Zhiyong Peng

Cell death & disease 11:508 PubMed32641713

2020

Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Yang,Meixi Peng,Yixuan Hou,Yilu Qin,Xueying Wan,Pengpeng Zhu,Shuiqing Liu,Liping Yang,Huan Zeng,Ting Jin,Yuxiang Qiu,Qiao Li,Manran Liu

Cancers 11: PubMed31783691

2019

Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in -Addicted Glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Heng-Wei Liu,Peter Mingjui Lee,Oluwaseun Adebayo Bamodu,Yu-Kai Su,Iat-Hang Fong,Chi-Tai Yeh,Ming-Hsien Chien,I-Hung Kan,Chien-Min Lin
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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