AB47328

Anti-Stathmin 1 (phospho S16) antibody

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(10 제품이 사용된 논문 )

Rabbit Polyclonal Stathmin 1 phospho S16 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human STMN1 pS16 aa 1-100.

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 (phospho S16) antibody (AB47328)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 (phospho S16) antibody (AB47328)

ab47328 staining human breast carcinoma tissue by IHC-P (left hand panel). The right hand panel shows staining in the presence of phospho-peptide.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human STMN1 pS16 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P16949

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

The antibody was affinity-purified using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Stathmin 1 also known as Oncoprotein 18 (Op18) is a cytoplasmic phosphoprotein weighing approximately 19 kDa. It functions primarily by regulating microtubule dynamics; it destabilizes microtubules and promotes depolymerization. Stathmin 1 achieves this by binding to tubulin heterodimers preventing their polymerization into microtubules. This protein is widely expressed in neurons immune cells and various cancer cell lines indicating its significant role in cellular processes.

Biological function summary

Stathmin 1 is important in cell cycle regulation and cell signaling. It does not operate as part of a larger protein complex but rather exerts its effects directly on microtubules. By overriding the stabilization of microtubules it ensures proper mitotic spindle function. This action is especially significant during the G2/M transition and mitosis contributing to the precise segregation of chromosomes.

Pathways

The regulation of microtubule dynamics by Stathmin 1 plays an important role in cell division and neuronal development. It is involved in the PI3K/AKT signaling pathway which ensures cell survival and proliferation. Stathmin 1 interacts with other regulatory proteins such as Tau which stabilizes microtubules offering a balance between dynamic instability and stabilization. This interaction highlights its involvement in cytoskeletal reorganization essential for both cancer progression and neuronal function.

The altered expression of Stathmin 1 is often associated with various cancers including breast and ovarian cancers. Overexpression leads to enhanced tumor growth and metastasis. It also plays a role in neurological disorders by affecting neuronal microtubules making it of particular interest in research on neurodegenerative diseases like Alzheimer's. Its interaction with proteins like Tau in the brain further connects it to these disorders as both are involved in microtubule modulation important for maintaining cell structure and function.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

See full target information STMN1 pS16

대체 명칭 보기

C1orf215, LAP18, OP18, STMN1, Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, Op18, pp19

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제품이 사용된 논문 (10)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 13: PubMed34771457

2021

NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C.

Applications

Unspecified application

Species

Unspecified reactive species

Lukas Funke,Thilo Bracht,Sebastian Oeck,Karin Schork,Markus Stepath,Sabine Dreesmann,Martin Eisenacher,Barbara Sitek,Alexander Schramm

Journal of cellular physiology 236:677-687 PubMed32654176

2020

FoxO1a mediated cadmium-induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking.

Applications

Unspecified application

Species

Unspecified reactive species

Doudou Jing,Wei Wu,Xiangyu Deng,Yizhong Peng,Wenbo Yang,Donghua Huang,Zengwu Shao,Dong Zheng

Chemosphere 211:758-766 PubMed30099160

2018

Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny.

Applications

Unspecified application

Species

Unspecified reactive species

Mingdan You,Weijia Gu,Mei Li,Zhenmin Qiu,Siyao Li,Zhixin Jiang,Dianqi Yao,Yuanyuan Xu,Yi Wang

International journal of molecular medicine 40:235-242 PubMed28534969

2017

The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Xian Chen,Ying Liao,Dan Long,Ting Yu,Fang Shen,Xuechi Lin

Oncotarget 7:33627-48 PubMed27144524

2016

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Stefan J Kempf,Athanasios Metaxas,María Ibáñez-Vea,Sultan Darvesh,Bente Finsen,Martin R Larsen

Oncogene 35:5412-5421 PubMed27041561

2016

RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

G N Alesi,L Jin,D Li,K R Magliocca,Y Kang,Z G Chen,D M Shin,F R Khuri,S Kang

Biomedical reports 3:28-32 PubMed25469242

2014

Increased stathmin expression strengthens fear conditioning in epileptic rats.

Applications

Unspecified application

Species

Unspecified reactive species

Linna Zhang,Danni Feng,Hong Tao,Xiangyan DE,Qing Chang,Qikuan Hu

The Journal of biological chemistry 289:2157-69 PubMed24302736

2013

cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Y Yip,Yvonne Y C Yeap,Marie A Bogoyevitch,Dominic C H Ng

FASEB journal : official publication of the Federa 26:3862-74 PubMed22700873

2012

Novel role of stathmin in microtubule-dependent control of endothelial permeability.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyong Tian,Yufeng Tian,Nicolene Sarich,Tinghuai Wu,Anna A Birukova

The Journal of biological chemistry 285:1343-57 PubMed19903810

2009

Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development.

Applications

ICC/IF, WB

Species

Rat, Rat

Alonso M Higuero,Lucía Sánchez-Ruiloba,Laura E Doglio,Francisco Portillo,José Abad-Rodríguez,Carlos G Dotti,Teresa Iglesias

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Stathmin 1 (phospho S16) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 (phospho S16) antibody (AB47328)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (10)

Product promise