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AB113230

Anti-STEAP4 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal STEAP4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human STEAP4 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

STAMP2, TNFAIP9, STEAP4, Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody (AB113230)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody (AB113230)

ab113230, at 10µg/ml, staining STEAP4 in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody (AB113230)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody (AB113230)

ab113230, at 10µg/ml, staining STEAP4 in Formalin-fixed, Paraffin-embedded Human Skin tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-STEAP4 antibody (AB113230)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-STEAP4 antibody (AB113230)

ab113230 at 1/100 dilution staining STEAP4 in HeLa cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human STEAP4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q687X5

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대체품

Primary Antibodies

AB140951

Anti-STEAP4 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STEAP4 antibody - N-terminal (AB140951)

  • 0
  • 0

보완 제품

Primary Antibodies

AB105731

Anti-AKT1 (phospho T308) antibody [18F3.H11]

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKT1 (phospho T308) antibody [18F3.H11] (AB105731)

  • 3
  • 2
Primary Antibodies

AB197023

Anti-HNRNPA0 antibody [EP16085]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HNRNPA0 antibody [EP16085] (AB197023)

  • 0
  • 0
Primary Antibodies

AB290723

Anti-STEAP1 antibody [EPR26044-70]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-STEAP1 antibody [EPR26044-70] (AB290723)

  • 0
  • 0
Primary Antibodies

AB133349

Anti-FGR antibody [EPR3171]

RabMAb|Recombinant

Western blot - Anti-FGR antibody [EPR3171] (AB133349)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

STEAP4 also known as STEAP4 metalloreductase or TIARP is a membrane-associated protein with a molecular mass of approximately 51 kDa. It mainly functions as a metalloreductase playing a role in the reduction of metal ions particularly iron and copper within cells. You find its expression in various tissues with higher levels in the adipose tissue liver and prostate. This protein is integral to cellular processes that require metal ion homeostasis influencing several pathways through its enzymatic activity on metal reduction.
Biological function summary

The function of STEAP4 extends beyond mere metal ion reduction. It contributes to cellular metabolism and inflammatory response regulation. Researchers have noted its involvement in the modulation of reactive oxygen species (ROS) which are important for detoxification and signaling. This protein does not function in isolation but may work in concert with other proteins in complexes related to the cell membrane and energy metabolism.

Pathways

STEAP4 participates in critical metabolic and inflammatory pathways. In particular it plays a role in the JNK and NF-kB signaling pathways which impact cellular stress responses and inflammation. Interactions with additional regulatory proteins such as TNF-alpha and IL-6 further integrate STEAP4 into these pathways linking its functions with larger cellular processes that respond to external stimuli and stress factors.

STEAP4 has important connections to metabolic and inflammatory conditions. Research shows its involvement in obesity-related inflammation and insulin resistance linking it with metabolic syndrome conditions. You also find associations between STEAP4 expression and type 2 diabetes as its dysfunction may impact glucose and lipid metabolism. This protein's interactions with TNF-alpha and IL-6 also suggest a strong link to chronic inflammatory states which can exacerbate metabolic disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed : 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed : 18381574, PubMed : 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed : 19660107). Inhibits anchorage-independent cell proliferation (PubMed : 19787193).
See full target information STEAP4
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer & metabolism 11:26 PubMed38111065

2023

STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Binhui Xie,Baiyin Zhong,Zhenxian Zhao,Jie Hu,Jianqiong Yang,Yuankang Xie,Jianhong Zhang,Jianting Long,Xuewei Yang,Heping Li

Journal of neurological surgery. Part B, Skull bas 78:371-379 PubMed28875114

2017

Comparative Proteomic Profiling Using Two-Dimensional Gel Electrophoresis and Identification via LC-MS/MS Reveals Novel Protein Biomarkers to Identify Aggressive Subtypes of WHO Grade I Meningioma.

Applications

Unspecified application

Species

Unspecified reactive species

Joshua W Osbun,Philip D Tatman,Sumanpreet Kaur,Carolina Parada,Tina Busald,Luis Gonzalez-Cuyar,Min Shi,Donald E Born,Jing Zhang,Manuel Ferreira
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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