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AB238340

Anti-STK38 antibody

4

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal STK38 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STK38 aa 1-200.

대체 명칭 보기

NDR1, STK38, Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38 antibody (AB238340)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38 antibody (AB238340)

Paraffin-embedded human testis tissue stained for STK38 using ab238340 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STK38 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q15208

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보완 제품

Primary Antibodies

AB9344

Anti-Phosphothreonine-Proline / Phosphoserine-Proline antibody

  • 0
  • 0
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB227978

Anti-ENO1 antibody [EPR19758]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENO1 antibody [EPR19758] (AB227978)

  • 0
  • 0
Primary Antibodies

AB9332

Anti-Phosphoserine antibody

Western blot - Anti-Phosphoserine antibody (AB9332)

  • 3
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

STK38 also known as NDR1 (nuclear Dbf2-related kinase 1) is a serine/threonine kinase with a molecular mass of approximately 54 kDa. It plays an important role in the regulation of cell proliferation and apoptosis through its involvement in phosphorylation processes. This protein is expressed in various tissues including the brain heart and muscle indicating its broad functional roles across different biological systems. Through its kinase activity STK38 modulates several intracellular pathways critical for maintaining cellular functions.
Biological function summary

STK38 is essential for regulating apoptosis and cell cycle progression. It acts as part of a larger signaling complex engaging in interactions with different proteins to exert its effects. Phosphorylation by STK38 often leads to activation or inhibition of downstream targets influencing cell survival and division. It can interact with MOB1 and LATS1/2 which highlights its role in the Hippo signaling pathway important for controlling organ size and suppressing tumors.

Pathways

The STK38 protein integrates itself into the Hippo and mTOR pathways. In the Hippo pathway its interactions with MOB1 and LATS proteins are important for regulating organ size and maintaining balance between cell growth and death. In the mTOR pathway STK38 influences metabolic processes and cell growth by modifying signal transduction that is critical for cellular homeostasis. These pathways are vital for normal cellular function and highlight the regulatory versatility of STK38.

STK38 plays a significant role in cancer and neurodegenerative diseases. Aberrant activity or expression levels of STK38 can contribute to the development of certain cancers due to dysregulated cell proliferation and survival. In neurodegenerative diseases improper functioning of STK38 can lead to loss of neuronal cell integrity and increased cell death. Through its interactions with cancer-related proteins such as YAP1 and neurologically relevant proteins alterations in STK38 signaling may exacerbate disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Acts as an ufmylation 'reader' in a kinase-independent manner : specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed : 32537488).
See full target information STK38
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 14:e0225511 PubMed31756206

2019

Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hye Sung Kim,Young Sil Kim,Chul Lee,Myung Soo Shin,Jae Wang Kim,Bo Gun Jang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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