AB243329

Anti-SULT1C2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal SULT1C2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SULT1C2 aa 1-150.

대체 명칭 보기

SULT1C1, SULT1C2, Sulfotransferase 1C2, ST1C2, Sulfotransferase 1C1, humSULTC2, SULT1C#1

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

Formalin-fixed, paraffin-embedded human stomach tissue stained for SULT1C2 with ab243329 at 1/20 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

Formalin-fixed, paraffin-embedded human small intestine tissue stained for SULT1C2 with ab243329 at 1/20 dilution in immunohistochemical analysis shows strong cytoplasmic poitivity in a subset of gladnular cells.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

Formalin-fixed, paraffin-embedded human kidney tissue stained for SULT1C2 with ab243329 at 1/20 dilution in immunohistochemical analysis shows moderate positivity in cells in tubules.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SULT1C2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O00338

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SULT1C2 also known as sulfotransferase family 1C member 2 is an enzyme that catalyzes the sulfonation of molecules. It belongs to the sulfotransferase family and exhibits a molecular mass of approximately 34.2 kDa. This enzyme primarily expresses in human tissues with notable expression in the liver intestine and fetal tissues. SULT1C2 adds sulfonate groups to hydroxyl groups on substrates which influences the molecules’ activity and solubility.

Biological function summary

Sulfotransferase family 1C member 2 participates in the metabolism and detoxification of hormones neurotransmitters and xenobiotics. This enzyme does not typically function as part of a larger protein complex but acts individually to modify and regulate the activity and excretion of its substrates. Through sulfonation SULT1C2 contributes to the regulation of hormone activity and assists in the chemical defense mechanism of the organism by aiding the elimination of potential toxins.

Pathways

The activity of SULT1C2 plays a significant role in the sulfation pathway. It is important in the modification process which affects molecules in the metabolism particularly those involved in drug metabolism and the detoxification processes. SULT1C2 interacts with other enzymes from the sulfotransferase family that also contribute to these metabolic pathways such as SULT1A1 and SULT1E1.

Improper function or regulation of sulfotransferase family 1C member 2 has connections with certain cancers and liver disorders. Abnormal sulfonation by SULT1C2 may impact hormone regulation which relates to proliferative diseases like breast cancer. Furthermore liver disorders can arise when detoxification processes are impaired. Other sulfotransferases like SULT1A1 often show similar associations with these conditions highlighting a broader relationship between sulfonation activity and disease states.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed : 10481272, PubMed : 10783263, PubMed : 9852044). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed : 10481272, PubMed : 9852044). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed : 9852044).

See full target information SULT1C2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer medicine 12:10738-10754 PubMed36880364

2023

Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Liya Jiang,Fang Xu,Chenglong Li,Ting Liu,Qianwei Zhao,Yixian Liu,Ying Zhao,Yamei Li,Zhendong Zhang,Xiaolei Tang,Jintao Zhang

Biotechnology and applied biochemistry 69:431-441 PubMed33655541

2021

Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR-455-5p/PARVA axis.

Applications

Unspecified application

Species

Unspecified reactive species

Huiming Yu,Zhifen Yu,Xiaowei Wang,Dazhao Wang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SULT1C2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1C2 antibody (AB243329)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise