JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB221990

Anti-Surf6 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal SURF6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SURF6 aa 200-300.

대체 명칭 보기

SURF-6, SURF6, Surfeit locus protein 6

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Surf6 antibody (AB221990)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Surf6 antibody (AB221990)

PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for Surf6 (green) using ab221990 at 4 μg/ml in ICC/IF.

Western blot - Anti-Surf6 antibody (AB221990)
  • WB

Supplier Data

Western blot - Anti-Surf6 antibody (AB221990)

All lanes:

Western blot - Anti-Surf6 antibody (ab221990) at 1/1000 dilution

All lanes:

RT4 (human urinary bladder cancer cell line) cell lysate

Predicted band size: 41 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SURF6 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

O75683

style
left-column

보완 제품

Primary Antibodies

AB87913

Anti-Coilin antibody [IH10]

BOND RX™ Validated|KO Validated

Immunocytochemistry - Anti-Coilin antibody [IH10] (AB87913)

  • 5
  • 3
Primary Antibodies

AB166630

Anti-Fibrillarin+Fibrillarin-like protein 1 antibody [EPR10823(B)] - Nucleolar Marker

RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Fibrillarin+Fibrillarin-like protein 1 antibody [EPR10823(B)] - Nucleolar Marker (AB166630)

  • 5
  • 2
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
Primary Antibodies

AB222065

Anti-POLR1A antibody

Immunocytochemistry/ Immunofluorescence - Anti-POLR1A antibody (AB222065)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Surf6 also known as SURF-6 or Surfeit locus protein 6 is a protein that acts mechanically within the cell nucleus. It is approximately 37 kDa in size and shows a nuclear localization. Surf6 expression takes place in a variety of cell types where it is often located in the nucleolus suggesting its role in ribosomal functions.
Biological function summary

Within the nucleolus Surf6 associates with rRNA processing and ribosome biogenesis. It serves as a nucleolar protein with a function in facilitating the maturation and assembly of pre-rRNA into functional ribosomal subunits. Surf6 is not known to form part of a larger complex but shows interactions with other nucleolar components implying a regulatory role in ribosome production.

Pathways

Elements involving Surf6 participate in the ribosome biogenesis pathway and the cell cycle regulation pathway. Surf6 has a documented association with the RNA polymerase I machinery which is important for rRNA transcription. Its function aligns with nucleolar proteins like nucleolin and fibrillarin which also regulate ribosomal RNA synthesis and processing.

Alterations in Surf6 expression or mutation can link to proliferative diseases such as cancer. Surf6's role in ribosome biogenesis ties it to tumors where excessive ribosome production supports uncontrolled cell division. Connections are evident with other proteins like p53 known for tumor suppressor activities highlighting Surf6's potential impact on cellular proliferation in oncogenic contexts.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).
See full target information SURF6
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Diabetology & metabolic syndrome 13:152 PubMed34963484

2021

MiR-423-5p activated by E2F1 promotes neovascularization in diabetic retinopathy by targeting HIPK2.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Xiao,Yinu Zhao,Hongjing Sun,Jia Xu,Wenjie Li,Limo Gao
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com