JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB97818

Anti-TATDN1 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal TATDN1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TATDN1 aa 1-200.
1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-TATDN1 antibody (AB97818)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TATDN1 antibody (AB97818)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ab97818 at 1/200 dilution. Bottom picture shows stain merged with DNA probe.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TATDN1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q6P1N9

style
left-column

보완 제품

Primary Antibodies

AB6326

Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker

Flow Cytometry (Intracellular) - Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker (AB6326)

  • 5
  • 104
Primary Antibodies

AB227244

Anti-PARP1 antibody

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-PARP1 antibody (AB227244)

  • 5
  • 6
Primary Antibodies

AB92552

Anti-PCNA antibody [EPR3821]

RabMAb|Lab Essentials|20ul selling size|Recombinant

Flow Cytometry (Intracellular) - Anti-PCNA antibody [EPR3821] (AB92552)

  • 5
  • 12
Primary Antibodies

AB193353

Anti-DNA Ligase IV/LIG4 antibody [EPR16531]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNA Ligase IV/LIG4 antibody [EPR16531] (AB193353)

  • 3
  • 4
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TATDN1 also known as TatD DNase domain-containing protein 1 functions mechanically as a deoxyribonuclease in eukaryotic cells. This protein has a mass of approximately 34 kDa and is expressed in various tissues including the heart skeletal muscle and testis. TATDN1's nuclease activity involves catalyzing the hydrolysis of phosphodiester bonds which is significant in DNA metabolism processes.
Biological function summary

TATDN1 participates in apoptosis wherein it promotes the degradation of nuclear DNA during cell death. TATDN1 associates with complexes involving DNA repair and maintenance indicating its role in maintaining genomic integrity. The protein's ability to localize in different cellular compartments suggests its involvement in multiple cellular processes further highlighting its functional versatility in cells.

Pathways

TATDN1 engages in processes linked to both DNA damage response and apoptosis. It operates within the apoptosis pathway interacting with proteins like caspases which are responsible for the execution phase of cell apoptosis. In the context of DNA repair pathways TATDN1 may associate with proteins involved in detecting and rectifying DNA strand irregularities linking it to a network that enhances cell survival under stress.

TATDN1 shows relevance in cancer and neurodegenerative diseases due to its roles in DNA repair and apoptosis. Aberrant regulation of TATDN1 has been implicated in cancer as its dysfunction could lead to unchecked cellular proliferation. Additionally in neurodegenerative diseases TATDN1's interactions with proteins such as p53 suggest its contribution to cellular malfunction and death aggravating disease progression.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity).
See full target information TATDN1

대체 명칭 보기

CDA11, TATDN1, Deoxyribonuclease TATDN1, DNA-(apurinic or apyrimidinic site) endonuclease TATDN1, Hepatocarcinoma high expression protein
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology letters 20:356 PubMed33133256

2020

Coiled-coil domain-containing 68 promotes non-small cell lung cancer cell proliferation .

Applications

Unspecified application

Species

Unspecified reactive species

Tao Hua,Jie Ding,Jialing Xu,Yu Fan,Zejie Liu,Juanwen Lian
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com