AB243031

Anti-THSD7A antibody [CL3778]

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(2 제품이 사용된 논문 )

Mouse Monoclonal THSD7A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human THSD7A aa 200-400.

대체 명칭 보기

KIAA0960, THSD7A, Thrombospondin type-1 domain-containing protein 7A

4 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human kidney tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Negative control - Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for THSD7A with ab243031 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Formalin-fixed, paraffin-embedded human testis tissue stained for THSD7A with ab243031 at a 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL3778

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human THSD7A aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UPZ6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

THSD7A also known as Thrombospondin Type-1 Domain Containing Protein 7A is a glycoprotein with a mass of approximately 250 kDa. The glycoprotein is expressed mainly in the kidneys and brain and to some extent in the placenta and lungs. This expression pattern suggests its potential role in the vascular system and nervous tissues. THSD7A is localized at endothelial cells where it is thought to interact with the extracellular matrix.

Biological function summary

THSD7A influences cell adhesion and migration processes. It plays a significant role in angiogenesis promoting the formation and maintenance of blood vessels. This protein often partners with integrins forming a complex that modulates various cellular interactions essential for vessel stability and permeability. THSD7A's involvement in the developing circulatory system signifies its importance in embryonic growth and development.

Pathways

This protein intersects the angiogenesis and cell adhesion pathways. Within these contexts THSD7A interacts with other proteins such as vascular endothelial growth factor (VEGF) and integrins which are critical for the angiogenesis process. These interactions facilitate proper cell signaling that ensures blood vessel formation and repair stressing its functional significance in vascular biology.

THSD7A has links with membranous nephropathy an autoimmune kidney condition. Autoantibodies against THSD7A are found in a subset of patients with this disease linking it directly to disease pathology. Additionally given its role in angiogenesis abnormalities in THSD7A expression or function may also relate to cancer progression where angiogenic imbalance plays a pivotal role. Understanding THSD7A's connection with VEGF during these disease states highlights it as an important target for therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Thrombospondin type-1 domain-containing protein 7A. Plays a role in actin cytoskeleton rearrangement.. Thrombospondin type-1 domain-containing protein 7A, soluble form. The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.

See full target information THSD7A

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC gastroenterology 25:179 PubMed40098080

2025

THSD7A as a novel prognostic factor for colorectal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Oktay Halit Aktepe,Olcay Kurtulan,Pinar Ezgi Dama,Ahmet Melih Arslan,Elif Atag,Meral Uner,Berfu Korucu,Aziz Karaoglu,Suayib Yalcin

Biomacromolecules 25:6485-6502 PubMed39214607

2024

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Doubková,Jarmila Knitlová,David Vondrášek,Adam Eckhardt,Tomáš Novotný,Martin Ošt'ádal,Elena Filová,Lucie Bačáková

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-THSD7A antibody [CL3778]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THSD7A antibody [CL3778] (AB243031)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise