AB231176

Anti-TIMP2 antibody

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Rabbit Polyclonal TIMP2 antibody. Suitable for WB and reacts with Recombinant fragment - Horse, Rat, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus.

대체 명칭 보기

Timp-2, Timp2, Metalloproteinase inhibitor 2, Tissue inhibitor of metalloproteinases 2, TIMP-2

4 이미지

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Rat placenta lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Recombinant horse TIMP2 protein

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow cerebrum lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow kidney lysate

Predicted band size: 24 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Cow

Applications

applications

Immunogen

Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O77717

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대체품

Primary Antibodies

AB180630

Anti-TIMP2 antibody

Western blot - Anti-TIMP2 antibody (AB180630)

Primary Antibodies

AB230511

Anti-TIMP2 antibody [F27P3A4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP2 antibody [F27P3A4] (AB230511)

Primary Antibodies

AB1828

Anti-TIMP2 antibody [3A4]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP2 antibody [3A4] (AB1828)

보완 제품

Assay Kits

AB270213

Human TIMP2 ELISA Kit

Recombinant|SimpleStep

ELISA - Human TIMP2 ELISA Kit (AB270213)

Primary Antibodies

AB92536

Anti-MMP2 antibody [EPR1184]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-MMP2 antibody [EPR1184] (AB92536)

Primary Antibodies

AB47637

Anti-TIM 4 antibody

Western blot - Anti-TIM 4 antibody (AB47637)

Primary Antibodies

AB52903

Anti-SMAD3 (pS423/425) + SMAD5 (pS463/465) + SMAD1 (pS463/465) + SMAD2 (pS465/467) antibody [EP823Y]

20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMAD3 (pS423/425) + SMAD5 (pS463/465 ) + SMAD1 (pS463/465) + SMAD2 (pS465/467) antibody [EP823Y] (AB52903)

Primary Antibodies

AB283575

Anti-MMP9 antibody [RM1020]

Flow Cytometry (Intracellular) - Anti-MMP9 antibody [RM1020] (AB283575)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Horse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

ab231176 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TIMP2 also known as Tissue Inhibitor of Metalloproteinases 2 mechanistically inhibits the activity of matrix metalloproteinases (MMPs). It binds to MMPs regulating the extracellular matrix's remodeling. The protein has a molecular mass of around 21 kDa. TIMP2 is expressed in various tissues including the brain liver and kidneys where it maintains a balance between matrix degradation and production.

Biological function summary

TIMP2 plays a significant role in tissue maintenance and repair by controlling extracellular matrix turnover. It forms complexes with MMPs such as MMP-2 inhibiting their proteolytic activities. The protein is also involved in cell proliferation and differentiation affecting processes like angiogenesis and wound healing. Its regulatory function aids in maintaining tissue homeostasis and preventing excessive matrix breakdown.

Pathways

TIMP2 is integral to the matrix metalloproteinase pathway and the regulation of endothelial cell migration. The protein interacts closely with other MMPs influencing their activation and modulation. Through these pathways TIMP2 holds an important position in cellular migration and signaling ensuring precise matrix remodeling in response to physiological needs.

TIMP2 has significant links with cancer and fibrosis. Dysregulation of TIMP2 expression or its imbalance with MMPs can contribute to tumor progression and metastasis due to uncontrolled matrix degradation. Additionally abnormal TIMP2 levels associate with fibrotic diseases where excessive tissue deposition occurs. TIMP2's interaction with proteins like MMP-9 and MMP-2 highlights its involvement in these pathological conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

See full target information Timp2

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Integrative cancer therapies 24:15347354251375464 PubMed40958203

2025

Sennoside A Modulates the Ferroptosis and Immune Evasion of Oral Squamous Cell Carcinoma Cells Through Inhibiting the NF-κB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaying Huo,Jianhua Qi,Qixuan Ren

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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