AB187297

Anti-TIMP3 antibody - C-terminal

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(2 제품이 사용된 논문 )

Rabbit Polyclonal TIMP3 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TIMP3 aa 150 to C-terminus.

대체 명칭 보기

Metalloproteinase inhibitor 3, Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (AB187297)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (AB187297)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human placenta tissue labeling TIMP3 with ab187297 at 2 μg/ml.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TIMP3 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P35625

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대체품

Primary Antibodies

AB39185

Anti-TIMP3 antibody - Carboxyterminal end

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - Carboxyterminal end (AB39185)

Primary Antibodies

AB93637

Anti-TIMP3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody (AB93637)

Primary Antibodies

AB61316

Anti-TIMP3 antibody [MM0036-7D3]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody [MM0036-7D3] (AB61316)

Primary Antibodies

AB231495

Anti-TIMP3 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP3 antibody - C-terminal (AB231495)

Primary Antibodies

AB213063

Anti-TIMP3 antibody - BSA and Azide free

Primary Antibodies

AB39184

Anti-TIMP3 antibody

Western blot - Anti-TIMP3 antibody (AB39184)

보완 제품

Assay Kits

AB119608

Human TIMP3 ELISA Kit (MIG-5)

Sandwich ELISA - Human TIMP3 ELISA Kit (MIG-5) (AB119608)

Primary Antibodies

AB86607

Anti-MMP2 antibody [6E3F8]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP2 antibody [6E3F8] (AB86607)

Primary Antibodies

AB283575

Anti-MMP9 antibody [RM1020]

Flow Cytometry (Intracellular) - Anti-MMP9 antibody [RM1020] (AB283575)

Primary Antibodies

AB41037

Anti-ADAMTS5 antibody

Western blot - Anti-ADAMTS5 antibody (AB41037)

Primary Antibodies

AB211926

Anti-TIMP1 antibody [EPR18352]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP1 antibody [EPR18352] (AB211926)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Tissue inhibitor of metalloproteinases 3 (TIMP3) is widely recognized for its role in inhibiting the activity of matrix metalloproteinases (MMPs). It has an approximate mass of 24 kDa and is often referred to by its alternate name MIG. TIMP3 is expressed in various tissues especially those involved in extracellular matrix composition such as the kidney and lungs. Its expression helps maintain the balance between matrix deposition and degradation which is critical for normal tissue homeostasis.

Biological function summary

The function of TIMP3 extends beyond mere inhibition of MMPs; it is also involved in regulating angiogenesis and apoptosis. TIMP3 forms complexes with extracellular matrix components acting as an anchor that modulates cell-matrix interactions. This capacity to bind to matrix elements enhances its inhibitory activity against proteases making it an important regulator of extracellular matrix integrity.

Pathways

TIMP3 plays significant roles in extracellular matrix remodeling and the inflammatory response. It participates in pathways involving structural organization and signaling mediation such as the NF-kB signaling cascade. TIMP3 regulates proteins like TNF-alpha and MMPs which are central to these pathways balancing inflammatory responses and tissue remodeling processes.

The imbalance of TIMP3 activity has been linked to chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD). In COPD impaired regulation of ECM turnover by TIMP3 leads to destructive lung tissue remodeling. In AMD the regulation of angiogenesis and degradation of ECM around the retina by TIMP3 is disturbed influencing disease progression. Its interaction with proteins such as VEGF is critical in these pathological contexts where altered TIMP3 expression or function can exacerbate disease states.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

See full target information TIMP3

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Histology and histopathology 38:1009-1016 PubMed36861878

2023

Treatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Yujing Wang,Shuling Yue,Feng Cai,Wen Zhu,Yuxiang Zhong,Juanjuan Chen,Chunyun Li

Hypertension (Dallas, Tex. : 1979) 71:894-903 PubMed29610266

2018

Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Li,Masao Kakoki,Marcela Smid,Kim Boggess,Jennifer Wilder,Sylvia Hiller,Carol Bounajim,Scott E Parnell,Kathleen K Sulik,Oliver Smithies,Nobuyo Maeda-Smithies

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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