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AB210930

Anti-TLR9 antibody [ABM4D70]

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Rat Monoclonal TLR9 antibody. Suitable for Flow Cyt, WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Tlr9 aa 600-900.

대체 명칭 보기

CD289, Toll-like receptor 9, Tlr9

2 이미지
Flow Cytometry - Anti-TLR9 antibody [ABM4D70] (AB210930)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-TLR9 antibody [ABM4D70] (AB210930)

Flow cytometric analysis of mouse splenocytes labeling TLR9 with ab210930 at 0.5 μg/106 cells (red) compared with negative control cells (green). Goat anti-mouse PE conjugate was used as secondary antibody.

Western blot - Anti-TLR9 antibody [ABM4D70] (AB210930)
  • WB

Supplier Data

Western blot - Anti-TLR9 antibody [ABM4D70] (AB210930)

All lanes:

Western blot - Anti-TLR9 antibody [ABM4D70] (ab210930) at 2 µg/mL

All lanes:

mouse small intestine lysate

Predicted band size: 115 kDa

false

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • 519 FITC

    FITC Anti-TLR9 antibody [ABM4D70]

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

ABM4D70

Isotype

IgG2a

Light chain 타입

kappa

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt, WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Tlr9 aa 600-900. The exact immunogen used to generate this antibody is proprietary information.

Q9EQU3

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대체품

Primary Antibodies

AB37154

Anti-TLR9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR9 antibody (AB37154)

  • 5
  • 1
Primary Antibodies

AB58864

FITC Anti-TLR9 antibody [5G5]

Flow Cytometry (Intracellular) - FITC Anti-TLR9 antibody [5G5] (AB58864)

  • 0
  • 0
Primary Antibodies

AB211012

Anti-TLR9 antibody [EPR21735]

20ul selling size|KO Validated|RabMAb|Recombinant

Immunoprecipitation - Anti-TLR9 antibody [EPR21735] (AB211012)

  • 0
  • 0
Primary Antibodies

AB187148

Anti-TLR9 antibody [EPR14964-2]

20ul selling size|BOND RX™ Validated|RabMAb|KO Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR9 antibody [EPR14964-2] (AB187148)

  • 0
  • 0
Primary Antibodies

AB134368

Anti-TLR9 antibody [26C593.2]

Western blot - Anti-TLR9 antibody [26C593.2] (AB134368)

  • 0
  • 0
Primary Antibodies

AB232933

Anti-TLR9 antibody [EPR21735] - BSA and Azide free

RabMAb|KO Validated|Recombinant

Immunoprecipitation - Anti-TLR9 antibody [EPR21735] - BSA and Azide free (AB232933)

  • 0
  • 0

보완 제품

Primary Antibodies

AB32537

Anti-ERK1 antibody [Y72]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-ERK1 antibody [Y72] (AB32537)

  • 5
  • 4
Primary Antibodies

AB219413

Anti-MyD88 antibody [EPR21824]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-MyD88 antibody [EPR21824] (AB219413)

  • 0
  • 0
Primary Antibodies

AB237365

Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769] (AB237365)

  • 0
  • 0
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TLR9 also known as Toll-like receptor 9 is a protein that detects unmethylated CpG motifs which are common in bacterial and viral DNA. This protein weighs about 116 kDa. It mainly expresses in plasmacytoid dendritic cells B cells and in epithelial cells of various tissues. TLR9 locates in the endoplasmic reticulum and translocates to endolysosomes upon activation which is essential for its detection function.
Biological function summary

TLR9 recognizes and binds to microbial DNA triggering an immune response. It is part of the Toll-like receptor family which plays an important role in the innate immune system. TLR9 engages in the formation of complexes with other molecules such as MyD88 an adaptor protein to propagate downstream signaling. This leads to the activation of transcription factors that stimulate cytokine production promoting inflammation and defense against infections.

Pathways

TLR9 participates significantly in the NF-kB activation pathway and the type I interferon signaling cascade. During these processes TLR9 interacts with proteins like IRAK4 and TRAF6. In the NF-kB pathway TLR9's role in the early immune response is coordinated with other Toll-like receptors to detect pathogen-related patterns and initiate adaptive immunity. Its influence on type I interferon signaling facilitates antiviral defense mechanisms.

TLR9's malfunction or altered expression associates with systemic lupus erythematosus (SLE) and cancer. In SLE overactivation of TLR9 leads to autoantibody production which worsens the disease. This can involve the protein BAFF which supports B cell proliferation. In cancer TLR9 can influence tumor growth and the tumor microenvironment affecting disease progression. Its modulation is being researched for therapeutic interventions in these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed : 31408613). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed : 14993594, PubMed : 17474149, PubMed : 18820679, PubMed : 18931679, PubMed : 21402738, PubMed : 25686612). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed : 14993594). Controls lymphocyte response to Helicobacter infection (PubMed : 17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).
See full target information Tlr9
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular medicine 43:2005-2014 PubMed30864693

2019

Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Wang,Xiaoguang Liu,Chao Kong,Xiao Liu,Ze Teng,Yunlong Ma,Lei Yong,Chen Liang,Guanping He,Shibao Lu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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