AB192619

Anti-TLT-1 antibody [EP15294]

20ul selling size
RabMAb
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Rabbit Monoclonal TLT-1 antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

TLT1, UNQ1825/PRO3438, TREML1, Trem-like transcript 1 protein, TLT-1, Triggering receptor expressed on myeloid cells-like protein 1

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-TLT-1 antibody [EP15294] (AB192619)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TLT-1 antibody [EP15294] (AB192619)

Immunofluorescent analysis of Jurkat cells (4% Paraformaldehyde-fixed, 0.1% tritonX-100 permeabilized) labeling TLT-1 with ab192619 at 1/50 dilution (1.6 μg/ml). A Goat anti rabbit IgG (Alexa Fluor488) at 1/400 dilution (ab150077) was used as secondary antibody. Counterstain : DAPI.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLT-1 antibody [EP15294] (AB192619)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLT-1 antibody [EP15294] (AB192619)

Immunohistochemical analysis of paraffin-embedded Human spleen tissue labeling TLT-1 with ab192619 at 1/1000 dilution (0.08μg/ml). A Ready to use HRP Polymer for Rabbit IgG (prediluted) was used as secondary. Counterstain : Hematoxylin.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP15294

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TLT-1 or TREM-like transcript 1 is a receptor expressed on platelets and megakaryocytes. Known for a mass of approximately 27 kDa TLT-1 belongs to the immunoglobulin superfamily. This receptor is a type I transmembrane protein and its expression is found mainly in the alpha-granules of resting platelets. During platelet activation TLT-1 translocates to the cell surface where it can participate in various cellular interactions.

Biological function summary

TLT-1 plays a significant role in hemostasis and inflammation. When considering its biological activity TLT-1 is not part of a larger protein complex but it can bind fibrinogen which facilitates clot formation and stability. This binding assists in the regulation of platelet aggregation and assists modulating the inflammatory response during vascular injury. Through its interactions at the molecular level TLT-1 enhances the overall efficiency of the clotting process.

Pathways

TLT-1 contributes to the hemostatic and pro-inflammatory pathways. It plays a part in the regulation of clot formation by interacting with other platelet surface proteins and fibrinogen. TLT-1 is associated with pathways such as the platelet activation pathway where it cooperates with proteins like P-selectin to modulate responses to vascular injury. Such interactions ensure that TLT-1 functions as an important component in maintaining circulatory system integrity.

TLT-1 connects to conditions such as thrombosis and sepsis. These disorders involve the dysfunction of the hemostatic and immune systems respectively. In thrombosis TLT-1 may contribute to excessive clot formation often interacting with proteins like fibrinogen in the process. During sepsis TLT-1 takes part in the inflammatory response which can exacerbate the clinical symptoms of the condition. Understanding the role of TLT-1 could aid in developing therapeutic targets aimed at modulating both coagulation and inflammation processes.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cell surface receptor that may play a role in the innate and adaptive immune response.

See full target information TREML1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of orthopaedic surgery and research 20:539 PubMed40442730

2025

Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yu,Ming Yang,Yun Jin,Kaijie Yang,Haibo Yang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TLT-1 antibody [EP15294]

Immunocytochemistry/ Immunofluorescence - Anti-TLT-1 antibody [EP15294] (AB192619)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLT-1 antibody [EP15294] (AB192619)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Assay Kits

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise