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AB67325

Anti-TMC6 antibody

5

(1 리뷰)

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(1 출판물)

Rabbit Polyclonal TMC6 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMC6.
1 이미지
Western blot - Anti-TMC6 antibody (AB67325)
  • WB

Unknown

Western blot - Anti-TMC6 antibody (AB67325)

Lane 1:

Western blot - Anti-TMC6 antibody (ab67325) at 1 µg/mL

Lane 2:

Western blot - Anti-TMC6 antibody (ab67325) at 2 µg/mL

All lanes:

A20 cell lysate at 15 µg

Predicted band size: 90 kDa

Observed band size: 90 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TMC6. The exact immunogen used to generate this antibody is proprietary information.

Q7Z403

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보완 제품

Assay Kits

AB139482

ER Staining Kit - Red Fluorescence - Cytopainter

Fluorescence Microscopy - ER Staining Kit - Red Fluorescence - Cytopainter (AB139482)

  • 4
  • 4
Primary Antibodies

AB137120

Anti-IMPDH2 + IMPDH1 antibody [EPR9678(B)]

RabMAb|Recombinant

Western blot - Anti-IMPDH2 + IMPDH1 antibody [EPR9678(B)] (AB137120)

  • 0
  • 0
Assay Kits

AB289842

Total Glycosaminoglycans Assay Kit (Colorimetric)

Functional Studies - Total Glycosaminoglycans Assay Kit (Colorimetric) (AB289842)

  • 0
  • 0
Assay Kits

AB108848

Human Fibronectin ELISA Kit

Competitive ELISA - Human Fibronectin ELISA Kit (AB108848)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMC6 also known as EVER1 is a protein implicated in the regulation of metal ion transport across cellular membranes. The protein has a molecular mass of approximately 89 kDa. TMC6 is widely expressed in several tissues with notable expression levels in keratinocytes and epithelial cells. It localizes to the endoplasmic reticulum membrane suggesting its involvement in ion homeostasis processes within the cell.
Biological function summary

The protein plays a significant role in maintaining cellular zinc levels. TMC6 is part of a complex with another protein called TMC8 involved in metal ion transport and potentially influencing immune response processes. This complex is essential for cellular metal homeostasis and disruptions in its function can lead to imbalances affecting cellular health. Its presence in keratinocytes suggests a particular importance in skin health and function.

Pathways

TMC6 interacts with the zinc regulation pathway which is essential for numerous cellular processes including enzyme function and gene expression. It also has connections to the immune response pathway where it might modulate responses influenced by metal ion levels. Within these pathways TMC8 often works alongside TMC6 to modulate the balance of zinc ions illustrating the close functional relationship between TMC6 and TMC8.

TMC6 is closely linked to skin disorders particularly epidermodysplasia verruciformis (EV) a rare condition that predisposes individuals to skin lesions and human papillomavirus (HPV) infections. Mutations in TMC6 can impair the immune system's ability to control HPV infections contributing to disease manifestation. This relationship highlights the interaction between TMC6 and HPV proteins illustrating its key role in maintaining skin integrity and immune defense against viral infections.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed : 18158319, PubMed : 30068544, PubMed : 32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed : 30068544, PubMed : 32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed : 18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed : 18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity).
See full target information TMC6

대체 명칭 보기

EVER1, EVIN1, TMC6, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Brain : a journal of neurology 137:2984-96 PubMed25234641

2014

Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures.

Applications

Unspecified application

Species

Unspecified reactive species

Morgane Boillot,Clément Huneau,Elise Marsan,Katia Lehongre,Vincent Navarro,Saeko Ishida,Béatrice Dufresnois,Ekim Ozkaynak,Jérôme Garrigue,Richard Miles,Benoit Martin,Eric Leguern,Matthew P Anderson,Stéphanie Baulac
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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