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AB113443

Anti-TMEM16B antibody

4

(3 리뷰들)

|

(1 출판물)

Rabbit Polyclonal TMEM16B antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANO2 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

C12orf3, TMEM16B, ANO2, Anoctamin-2, Transmembrane protein 16B

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM16B antibody (AB113443)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM16B antibody (AB113443)

ab113443, at 5 µg/ml, staining TMEM16B in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM16B antibody (AB113443)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM16B antibody (AB113443)

ab113443, at 5 µg/ml, staining TMEM16B in formalin fixed, paraffin embedded Human small intestine tissue by Immunohistochemistry.

Western blot - Anti-TMEM16B antibody (AB113443)
  • WB

Unknown

Western blot - Anti-TMEM16B antibody (AB113443)

Lane 1:

Western blot - Anti-TMEM16B antibody (ab113443) at 1 µg/mL

Lane 2:

Western blot - Anti-TMEM16B antibody (ab113443) at 2 µg/mL

All lanes:

Rat brain tissue lysate

Predicted band size: 114 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ANO2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9NQ90

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대체품

Primary Antibodies

AB91573

Anti-TMEM16B antibody

Immunocytochemistry/ Immunofluorescence - Anti-TMEM16B antibody (AB91573)

  • 0
  • 1

보완 제품

Primary Antibodies

AB64085

Anti-TMEM16A antibody [SP31]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TMEM16A antibody [SP31] (AB64085)

  • 3
  • 2
Primary Antibodies

AB234422

Anti-ANO6 antibody [EPR20910-105]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-ANO6 antibody [EPR20910-105] (AB234422)

  • 0
  • 0
Primary Antibodies

AB181663

Anti-anoctamin 5 antibody

  • 0
  • 0
Primary Antibodies

AB32370

Anti-Bcl-XL antibody [E18]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-XL antibody [E18] (AB32370)

  • 5
  • 10
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMEM16B also known as ANO2 is a calcium-activated chloride channel with a mass of around 116 kDa. It plays a role in ion transport across the cell membrane. TMEM16B is expressed in various tissues most notably in the sensory neurons and the retina where it contributes to the function of sensory systems. Its activity depends on calcium presence allowing the passage of chloride ions which affects membrane potential and cellular signaling.
Biological function summary

TMEM16B influences processes like odor detection and vision. It acts as a component of a larger channel complex involved in the transduction of sensory signals. In olfactory sensory neurons TMEM16B modulates the signaling pathway by which odors lead to nerve impulses making it important for the sense of smell. In the retina it plays a role in photoreceptor signal regulation supporting proper vision.

Pathways

Protein TMEM16B interacts within the sensory transduction pathways including the visual and olfactory pathways. In the olfactory system it works with proteins like CNGA2 in the signaling cascade from odorant molecules to neuronal response. In the visual pathway TMEM16B collaborates with proteins involved in the phototransduction cascade impacting the conversion of light into electrical signals necessary for vision.

TMEM16B's malfunction links to anosmia and certain retinal degenerations. Alterations in its activity can lead to loss of smell as TMEM16B is necessary for signal propagation in olfactory neurons. In the retina its dysfunction may contribute to degenerative diseases linking with proteins like rhodopsin which plays a role in light detection. Understanding TMEM16B's role provides insight into these sensory disorders potentially guiding therapeutic strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
See full target information ANO2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in molecular neuroscience 14:688050 PubMed34630032

2021

Tandem Mass Tag-Based Quantitative Proteomic Analysis Reveals Pathways Involved in Brain Injury Induced by Chest Exposure to Shock Waves.

Applications

Unspecified application

Species

Unspecified reactive species

Changci Tong,Peifang Cong,Ying Liu,Xiuyun Shi,Lin Shi,Shun Mao,Yan Zhao,Mingxiao Hou,Yunen Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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