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AB126292

Anti-TMEM208 antibody

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(1 출판물)

Rabbit Polyclonal TMEM208 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM208.

대체 명칭 보기

HSPC171, TMEM208, Transmembrane protein 208

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM208 antibody (AB126292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM208 antibody (AB126292)

ab126292, at 1/20 dilution, staining TMEM208 in paraffin-embedded Human placenta tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMEM208. The exact immunogen used to generate this antibody is proprietary information.

Q9BTX3

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보완 제품

Primary Antibodies

AB207305

Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-SQSTM1 / p62 antibody [EPR18351] - Autophagosome Marker (AB207305)

  • 5
  • 3
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB51520

Anti-LC3B antibody

Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-LC3B antibody (AB51520)

  • 4
  • 18
Primary Antibodies

AB108338

Anti-ATG9A antibody [EPR2450(2)]

RabMAb|Recombinant|KO Validated|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-ATG9A antibody [EPR2450(2)] (AB108338)

  • 5
  • 15
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMEM208 also known as transmembrane protein 208 plays a role in cellular processes involving the endoplasmic reticulum and lysosomes. With an estimated molecular weight of around 24 kDa scientist can find TMEM208 predominantly expressed in human tissues particularly in the heart and skeletal muscle. As a multi-pass membrane protein TMEM208 establishes the cell organelles' communication ensuring intracellular stability and proper functioning of cellular processes.
Biological function summary

The protein serves an essential function in the formation and maintenance of autophagic vesicles. It operates as a component of the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) participating in cargo sorting and transport. TMEM208's role in vesicle nucleation is important for autophagy a process where cells remove unnecessary or dysfunctional components maintaining cellular homeostasis. This action indirectly supports cellular adaptation to stress.

Pathways

TMEM208 integrates into intracellular trafficking and autophagy pathways working alongside proteins such as LC3 and ATG-related proteins. Through its involvement in vesicular transport TMEM208 collaborates in the lysosomal degradation pathway a process important for recycling cellular materials. TMEM208's interaction with LC3 connects it to the macroautophagy pathway allowing the cell to respond effectively to nutrient deprivation or other cellular stressors.

TMEM208 associates with pathologies linked to improper autophagic processes and cellular stress responses including neurodegenerative diseases like Alzheimer's and possibly myopathies. Researchers note its association with proteins such as p62 which accumulates when autophagy is disrupted indicating TMEM208's potential role in disease progression. Understanding TMEM208's function might lead to identifying therapeutic targets for these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
See full target information TMEM208
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 17:2153-2160 PubMed29207124

2017

Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Zhou,Yi Zhao,Lingping Gu,Xiaoming Niu,Shun Lu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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