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AB236854

Anti-TMEM53 antibody

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Rabbit Polyclonal TMEM53 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM53 aa 1-200.

대체 명칭 보기

NET4, TMEM53, Transmembrane protein 53, Nuclear envelope transmembrane protein 4

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM53 antibody (AB236854)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM53 antibody (AB236854)

Paraffin-embedded human pancreatic cancer tissue stained for TMEM53 using ab236854 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TMEM53 antibody (AB236854)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TMEM53 antibody (AB236854)

A549 (human lung carcinoma cell line) cells stained for TMEM53 (green) using ab236854 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TMEM53 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q6P2H8

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보완 제품

Primary Antibodies

AB236891

Anti-PTGR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR2 antibody (AB236891)

  • 0
  • 0
Primary Antibodies

AB194319

Alexa Fluor® 647 Anti-VCAM1 antibody [EPR5047]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 647 Anti-VCAM1 antibody [EPR5047] (AB194319)

  • 5
  • 1
Primary Antibodies

AB230822

Anti-BMAL1 antibody [EPR23696-22]

BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-BMAL1 antibody [EPR23696-22] (AB230822)

  • 0
  • 0
Assay Kits

AB176660

ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187) + Total ELISA Kit

SimpleStep

ELISA - ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187) + Total ELISA Kit (AB176660)

  • 5
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMEM53 also known as Transmembrane Protein 53 is a protein that functions primarily as a transmembrane protein. It is composed of 190 amino acids giving it a molecular weight of approximately 22 kDa. TMEM53 is expressed across various tissues but it shows notably high expression in the liver and kidney. Structurally it includes multiple transmembrane domains which suggest its role in cellular transport or signaling processes.
Biological function summary

TMEM53 contributes to maintaining cellular homeostasis and signaling. It has been implicated in various cellular pathways where it helps regulate ion transport across membranes. Though not part of any known complex TMEM53 interacts with components of the cell membrane influencing cellular responses to external stimuli. The protein's ubiquitous presence in body tissues highlights its broad functional roles.

Pathways

TMEM53 engages in signal transduction and ion transport pathways. One example is the calcium signaling pathway where it regulates intracellular calcium levels. The protein works alongside ion transporters like SLC8A1 also known as the sodium/calcium exchanger to modulate cellular ion balance. Its pathway involvement points to interactions with other transmembrane proteins that support cellular communication and nutrient exchange.

TMEM53 has been connected to hypertension and kidney disease. Research indicates that alterations in TMEM53 expression or function can influence blood pressure regulation. This connection seems related to its role in sodium transport pathways similar to the actions of proteins like ENaC the epithelial sodium channel. Additionally changes in TMEM53 activity can impact kidney function leading to chronic kidney disorders highlighting its relevance in renal health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins.
See full target information TMEM53
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 14:1171308 PubMed37325657

2023

Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils.

Applications

Unspecified application

Species

Unspecified reactive species

Aina Zhou,Chenxi Shi,Yuhui Fan,Yushuang Zheng,Jue Wang,Zhichen Liu,Huanxia Xie,Jisheng Liu,Qingqing Jiao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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