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AB121333

Anti-TMIGD2/IGPR1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal TMIGD2/IGPR1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMIGD2 aa 1-150.

대체 명칭 보기

CD28H, IGPR1, UNQ3059/PRO9879, TMIGD2, Transmembrane and immunoglobulin domain-containing protein 2, CD28 homolog, Immunoglobulin and proline-rich receptor 1, IGPR-1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)

ab121333, at 1/50, staining TMIGD2/IGPR1 in paraffin embedded Human duodenum tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TMIGD2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q96BF3

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보완 제품

Primary Antibodies

AB209242

Anti-B7H4 antibody [EPR20236]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B7H4 antibody [EPR20236] (AB209242)

  • 0
  • 0
Primary Antibodies

AB315994

Anti-HHLA2 antibody [EPR26395-88]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA2 antibody [EPR26395-88] (AB315994)

  • 0
  • 0
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

  • 0
  • 0
Primary Antibodies

AB192033

Anti-Nectin-4 antibody [EPR15613-68]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Nectin-4 antibody [EPR15613-68] (AB192033)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMIGD2 also known as IGPR1 (Immuno-Glycosylation Promoting Receptor 1) is a protein that functions as a transmembrane receptor. It has a molecular weight of approximately 50 kDa. TMIGD2 is expressed on the surface of endothelial cells and some lymphocytes notably T cells. The protein has a specific expression pattern which restricts it to certain tissues indicating its specialized role in cellular communication and interaction.
Biological function summary

This protein functions in the regulation of cell-cell adhesions impacting cell signaling and the maintenance of endothelial barriers. TMIGD2/IGPR1 does not function alone but associates homophilically binding to itself on adjacent cells to mediate cellular communication. This interaction plays a pivotal role in stabilizing intercellular connections which are essential for the proper function of vascular systems. Studies suggest its role in modulating immune cell interactions and migration.

Pathways

TMIGD2/IGPR1 interfaces significantly with the cellular adhesion and immune response pathways. It is involved in adhesive interactions that are integral to the function of these pathways. TMIGD2 interacts with proteins involved in the vascular endothelial growth factor (VEGF) pathway influencing angiogenesis and vascular integrity. Additionally it has links to the cell signaling pathways involving integrins which serve as important mediators in cellular attachment and migration.

Research associates TMIGD2/IGPR1 with vascular-related conditions such as atherosclerosis and inflammation-related diseases. Its expression patterns influence endothelial cell response and immune cell trafficking important elements in these conditions. In atherosclerosis the protein's interaction with adhesion molecules like ICAM-1 and VCAM-1 can alter the inflammatory environment influencing disease progression. In inflammatory diseases TMIGD2's modulatory effects on immune cell dynamics can exacerbate or alleviate disease states depending on the context.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
See full target information TMIGD2
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in oncology 15:1524861 PubMed40061889

2025

Prognostic significance of the inhibitory-to-stimulatory immune checkpoint ratio in patients with breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chuangang Tang,Xiang Hu,Dawei Hao,Tao Chen,Pei Wang,Changwen Li,Chengling Chen,Yongcheng Li,Xiaowen Hao,Zeng Yuan

Biochemical genetics 59:453-474 PubMed33098307

2020

miR-491-3p is Downregulated in Retinoblastoma and Inhibit Tumor Cells Growth and Metastasis by Targeting SNN.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Hu,Ming Zhao,Li Li,Jie Ding,Yu-Min Gui,Tan-Wei Wei
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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