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AB234860

Anti-TP53I11 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal TP53I11 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TP53I11 aa 1-50.

대체 명칭 보기

PIG11, TP53I11, Tumor protein p53-inducible protein 11, p53-induced gene 11 protein

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-TP53I11 antibody (AB234860)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TP53I11 antibody (AB234860)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling TP53I11 (green) using ab234860 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TP53I11 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O14683

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보완 제품

Primary Antibodies

AB183597

Anti-Apolipoprotein E antibody [EPR19392]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Apolipoprotein E antibody [EPR19392] (AB183597)

  • 0
  • 0
Primary Antibodies

AB90716

Anti-Prosurfactant Protein C antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody (AB90716)

  • 4
  • 12
Primary Antibodies

AB183510

Anti-ARL2 antibody [EPR14436]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ARL2 antibody [EPR14436] (AB183510)

  • 4
  • 1
Primary Antibodies

AB121332

Anti-LRRN1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN1 antibody (AB121332)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TP53-induced protein 11 (TP53I11) also known as PIG11 is involved in p53-mediated cell signaling pathways. TP53I11 has a molecular weight of approximately 18 kDa. The protein predominantly expresses in tissues undergoing stress or DNA damage where it contributes to cellular responses such as cell cycle regulation and apoptosis. Through its association with p53 TP53I11 plays a part in sustaining cellular integrity by promoting the repair of damaged DNA or the elimination of cells when repair is not possible.
Biological function summary

TP53-induced protein 11 functions in pro-apoptotic pathways that safeguard cells against oncogenic transformation. It acts as a component of larger complexes engaged in cell cycle arrest and apoptosis induction. This protein participates in regulatory functions that determine cell fate emphasizing its involvement in preventing aberrant cell proliferation. TP53I11 collaborates with other p53 target genes to ensure the proper cellular outcomes under stress conditions.

Pathways

TP53I11 plays a significant role in the p53 signaling pathway and cell cycle control pathways. Within these pathways it interacts with p53 a critical tumor suppressor protein to promote cellular responses such as apoptosis. TP53I11 structurally and functionally links with other proteins like BAX involved in the execution of cell death processes thereby maintaining cellular homeostasis and preventing neoplastic growth.

TP53I11 show connections to cancer and neurodegenerative diseases. In many cancers mutations in p53 disrupt the regulation of TP53I11 leading to unchecked cell proliferation. The protein also associates with neurodegenerative processes as proper function is necessary to prevent neuronal death and maintain brain health. Related proteins including other p53-dependent proteins like PIG3 often share its role in these pathological conditions highlighting the importance of balanced TP53I11 activity in disease prevention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information TP53I11
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biomolecules 15: PubMed39858544

2025

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Colette B Rogers,Wendy Leung,Ryan M Baxley,Rachel E Kram,Liangjun Wang,Joseph P Buytendorp,Khoi Le,David A Largaespada,Eric A Hendrickson,Anja-Katrin Bielinsky

Heliyon 10:e29504 PubMed38655349

2024

An integrated analysis revealing the angiogenic function of TP53I11 in tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Bai,Jun-Song Ren,Ke-Ran Li,Qin Jiang

European journal of histochemistry : EJH 66: PubMed36190397

2022

Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jinbi Xie,Yong Ning,Lihang Zhang,Yuan Lin,Runsheng Guo,Shanjuan Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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