AB234819

Anti-TPD52L2 antibody

Name: Anti-TPD52L2 antibody
Brand: Abcam Limited
SKU: AB234819
Rating: 5 (4 reviews)

(4 리뷰들)

(3 제품이 사용된 논문 )

Rabbit Polyclonal TPD52L2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TPD52L2.

대체 명칭 보기

Tumor protein D54, hD54, Tumor protein D52-like 2, TPD52L2

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPD52L2 antibody (AB234819)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPD52L2 antibody (AB234819)

Paraffin-embedded human spleen tissue stained for TPD52L2 using ab234819 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPD52L2 antibody (AB234819)

Paraffin-embedded human pancreatic cancer tissue stained for TPD52L2 using ab234819 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-TPD52L2 antibody (AB234819)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TPD52L2 antibody (AB234819)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for TPD52L2 green) using ab234819 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488^® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TPD52L2.

O43399

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein TPD52L2 also known as Tumor Protein D52-like 2 and PrLZ plays a role in intracellular transport and secretion by interacting with membranes and acting as a vesicle-associated protein. It has a molecular weight of approximately 24 kDa. TPD52L2 gets highly expressed in several tissues including pancreas prostate and hematopoietic system. Moreover TPD52L2 localizes in cytoplasm and associates with secretory granules and lysosomal membranes.

Biological function summary

TPD52L2 contributes to processes such as cell proliferation and survival. It is associated with the regulation of exocytosis because of its presence in vesicles. TPD52L2 forms part of a broader protein family with conserved coiled-coil domains suggesting a capacity for protein-protein interactions. This family can affect the organization and dynamics of the cytoskeleton which is important for cytokinesis and endocytosis.

Pathways

TPD52L2 interacts directly with cellular communication and transport pathways. It is known to participate in the tumorigenesis pathway by modulating cell growth and apoptosis. The protein has interactions with key components such as PKB/AKT an important player in signaling cascades that regulate cell survival and metabolism. As a part of these pathways TPD52L2 may contribute to oncogenic transformation.

TPD52L2 has implications in cancer and metabolic disorders. Elevated levels of TPD52L2 have been linked to prostate cancer development where it interacts with proteins like FAK which are important for cancer cell migration and spread. Additionally altered expression of TPD52L2 could impact insulin signaling pathways contributing to conditions such as diabetes. Here its association with IRS proteins further illustrates the impact TPD52L2 may have within these pathologies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information TPD52L2

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 16: PubMed39199657

2024

Development of Ex Vivo Analysis for Examining Cell Composition, Immunological Landscape, Tumor and Immune Related Markers in Non-Small-Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Elena G Ufimtseva,Margarita S Gileva,Ruslan V Kostenko,Vadim V Kozlov,Lyudmila F Gulyaeva

Cancer biology & therapy 25:2385172 PubMed39097779

2024

KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Zhang,Zhihan Li,Jiaxu Han,Zhongtao Tian,Qingyu Meng,Wenbo Niu

Molecular medicine reports 24: PubMed34080022

2021

SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chiyang Li,Chengshuo Fei,Junjie Li,Hang Wu,Lei Chen,Ramzi Roshani,Hong Li,Linyong Shi,Chong Song,Junwei Gu,Yuntao Lu,Qiang Zhou

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TPD52L2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPD52L2 antibody (AB234819)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPD52L2 antibody (AB234819)

Immunocytochemistry/ Immunofluorescence - Anti-TPD52L2 antibody (AB234819)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise