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AB240562

Anti-TRAP alpha/TRAPA antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal TRAP alpha/TRAPA antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SSR1 aa 200-300.

대체 명칭 보기

TRAPA, PSEC0262, SSR1, Translocon-associated protein subunit alpha, TRAP-alpha, Signal sequence receptor subunit alpha, SSR-alpha

1 이미지
Western blot - Anti-TRAP alpha/TRAPA antibody (AB240562)
  • WB

Supplier Data

Western blot - Anti-TRAP alpha/TRAPA antibody (AB240562)

All lanes:

Western blot - Anti-TRAP alpha/TRAPA antibody (ab240562) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 10 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 10 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 10 µg

Lane 4:

TCMK-1 (mouse kidney epithelial cell line) whole cell lysate at 10 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 10 µg

Predicted band size: 32 kDa

true

Exposure time: 3min

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SSR1 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

P43307

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대체품

Primary Antibodies

AB133238

Anti-TRAP alpha/TRAPA antibody [EPR5603]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TRAP alpha/TRAPA antibody [EPR5603] (AB133238)

  • 0
  • 0
Primary Antibodies

AB126775

Anti-TRAP alpha/TRAPA antibody [EPR5604]

RabMAb|Recombinant

Western blot - Anti-TRAP alpha/TRAPA antibody [EPR5604] (AB126775)

  • 0
  • 0

보완 제품

Assay Kits

AB222942

Total Collagen Assay Kit (Perchlorate-Free)

Functional Studies - Total Collagen Assay Kit (Perchlorate-Free) (AB222942)

  • 4
  • 1
Primary Antibodies

AB186735

Anti-TOMM20 antibody [EPR15581-54] - Mitochondrial Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-TOMM20 antibody [EPR15581-54] - Mitochondrial Marker (AB186735)

  • 5
  • 16
Primary Antibodies

AB169538

Anti-RPL8 antibody [EPR11630]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-RPL8 antibody [EPR11630] (AB169538)

  • 0
  • 0
Primary Antibodies

AB187647

Anti-Cathepsin K antibody [EP9403]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin K antibody [EP9403] (AB187647)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
보관 버퍼
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRAP alpha also known as TRAPA or SSR1 is a protein with a mass of approximately 34 kDa. It locates within the endoplasmic reticulum (ER) membrane as a subunit of the translocon-associated protein complex. It has a role in maintaining the translocation of proteins across the endoplasmic reticulum membrane. TRAP alpha is widely expressed in various tissues reflecting its significant function in cellular processes.
Biological function summary

This protein serves as an integral component of the translocon complex facilitating protein transport into the ER. The TRAP complex includes several subunits that work together to ensure protein maturation and folding. TRAP alpha is especially essential for proper protein synthesis and quality control. It plays an important part in cellular homeostasis by ensuring that only correctly assembled proteins proceed to subsequent cellular pathways.

Pathways

TRAP alpha integrates into protein targeting and translocation pathways. It closely engages with the Sec61 complex another fundamental protein in translocation processes. TRAP alpha’s role is important in the secretory pathway which directs proteins destined for different organelles or secretion out of the cell. This pathway is interconnected with other cellular processes like the unfolded protein response ensuring cellular adaptation to stress conditions.

TRAP alpha associates with pathologies such as cystic fibrosis due to its involvement in protein processing. Mutations in proteins associated with TRAP alpha like CFTR can disrupt proper protein folding and cause disease. Additionally there are links between TRAP alpha and certain neurodegenerative conditions as defects in protein handling and folding within the ER can lead to cell death. Such associations also involve proteins like amyloid precursor protein underlining the importance of TRAP alpha in cellular health and disease prevention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
See full target information SSR1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular & cellular proteomics : MCP 24:100920 PubMed39880084

2025

Localized K63 Ubiquitin Signaling Is Regulated by VCP/p97 During Oxidative Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Austin O Maduka,Sandhya Manohar,Matthew W Foster,Gustavo M Silva

Journal of Cancer 15:5786-5809 PubMed39308676

2024

Prognostic and Immunological Role of Cuproptosis-Related Gene MTF1 in Pan-Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Zhang,Sifen Wang,Hailin Tang,Renchun Lai,Qiaoting Cai,Yaorong Su,Hao Wu,Yongwen Huang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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