AB111848

Anti-TRAPPC2 antibody [EPR3401]

RabMAb
Recombinant
각 태그의 뜻

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(2 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal TRAPPC2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

대체 명칭 보기

SEDL, TRAPPC2, Trafficking protein particle complex subunit 2, Sedlin

1 이미지

Unknown

Western blot - Anti-TRAPPC2 antibody [EPR3401] (AB111848)

All lanes:

Western blot - Anti-TRAPPC2 antibody [EPR3401] (ab111848) at 1/1000 dilution

Lane 1:

Human spleen cell lysate at 10 µg

Lane 2:

Raji cell lysate at 10 µg

Lane 3:

Daudi cell lysate at 10 µg

Predicted band size: 16 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3401

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRAPPC2 also known as sedlin is a component of the transport protein particle (TRAPP) complex with a molecular mass of approximately 17 kDa. It is a small protein that has a significant role in vesicular trafficking within cells. TRAPPC2 is expressed widely in human tissues with notable levels in the testis skeletal muscle and heart. This protein participates in the regulation of intracellular transport processes by assembling into multi-subunit complexes that facilitate the movement of vesicles.

Biological function summary

TRAPPC2 plays a role in the formation and function of the TRAPP complex which is fundamental for intracellular vesicle trafficking. The TRAPP complex exists in different forms and participates in the tethering of vesicles to target membranes. TRAPPC2’s involvement in this complex influences ER-Golgi transportation impacting how proteins and lipids move inside cells. By working as part of the TRAPP complex TRAPPC2 contributes to the maintenance of cellular homeostasis by controlling the flow and direction of cargo.

Pathways

TRAPPC2 is involved in the secretory pathway which is essential for protein sorting and transport. It interacts with other TRAPP subunits such as TRAPPC3 and TRAPPC9 to ensure effective vesicle fusion and trafficking processes. In addition to the secretory pathway TRAPPC2 is engaged in the autophagy pathway. Through its participation in these pathways TRAPPC2 affects how cells manage and recycle cellular components under varying conditions.

Mutations in TRAPPC2 are linked to X-linked spondyloepiphyseal dysplasia tarda a skeletal disorder affecting bone growth and development. The deficiency of TRAPPC2 disrupts normal vesicular trafficking ultimately leading to the symptoms observed in this disorder. TRAPPC2’s interactions with proteins such as TRAPPC3 and TRAPPC9 through these pathways underline its significance in maintaining cellular functions that when altered result in specific pathological states.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.

See full target information TRAPPC2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science advances 6: PubMed33208359

2020

Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Ke,Meiqian Weng,Gaurav Chhetri,Muhammad Usman,Yan Li,Qing Yu,Yingzhuo Ding,Zejian Wang,Xiaolong Wang,Pinky Sultana,Marian DiFiglia,Xueyi Li

Scientific reports 7:10751 PubMed28883641

2017

Calaxin establishes basal body orientation and coordinates movement of monocilia in sea urchin embryos.

Applications

Unspecified application

Species

Unspecified reactive species

Katsutoshi Mizuno,Kogiku Shiba,Junko Yaguchi,Daisuke Shibata,Shunsuke Yaguchi,Gérard Prulière,Janet Chenevert,Kazuo Inaba

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRAPPC2 antibody [EPR3401]

Western blot - Anti-TRAPPC2 antibody [EPR3401] (AB111848)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise