JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235394

Anti-TRAPPC6B antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal TRAPPC6B antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Trafficking protein particle complex subunit 6B aa 1-150.

대체 명칭 보기

Trafficking protein particle complex subunit 6B, TRAPP complex subunit 6B, TRAPPC6B

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)

Paraffin-embedded human adrenal gland tissue stained for TRAPPC6B with ab235394 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAPPC6B antibody (AB235394)

Paraffin-embedded human pancreas tissue stained for TRAPPC6B with ab235394 (1/100 dilution) in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Trafficking protein particle complex subunit 6B aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q86SZ2

style
left-column

보완 제품

Primary Antibodies

AB241382

Anti-YKT6 antibody

Immunoprecipitation - Anti-YKT6 antibody (AB241382)

  • 0
  • 0
Primary Antibodies

AB236883

Anti-TSPAN6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPAN6 antibody (AB236883)

  • 0
  • 0
Primary Antibodies

AB267377

Anti-Wilms Tumor Protein antibody [EPR23963-116]

BOND RX™ Validated|20ul selling size|Recombinant|KO Validated|Advanced Validation|RabMAb

Multiplex immunohistochemistry - Anti-Wilms Tumor Protein antibody [EPR23963-116] (AB267377)

  • 0
  • 0
Primary Antibodies

AB234832

Anti-ZMPSTE24 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMPSTE24 antibody (AB234832)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRAPPC6B also known as Trafficking Protein Particle Complex Subunit 6B is a component of the TRAPP complex which plays a role in vesicle-mediated transport within cells. TRAPPC6B is a protein with a molecular mass of approximately 16 kDa. It is expressed in various tissues including the liver kidney and brain indicating its broad involvement in cellular processes across different cell types.
Biological function summary

TRAPPC6B is involved in regulating intracellular trafficking particularly in the early steps of the secretory pathway. As part of the TRAPP complex it contributes to the tethering of COPII vesicles to Golgi membranes facilitating transport between the endoplasmic reticulum and Golgi apparatus. This action helps maintain cellular homeostasis and proper distribution of proteins and lipids within cells.

Pathways

TRAPPC6B is significant in the ER-Golgi transport pathway where it interacts with other subunits of the TRAPP complex including TRAPPC2 and TRAPPC3. These interactions are important for the assembly and function of the TRAPP complex in vesicle tethering. TRAPPC6B also plays a role in the macroautophagy pathway affecting the biogenesis of autophagosomes which are essential for cellular degradation and recycling processes.

TRAPPC6B has been implicated in neurodevelopmental disorders and is linked to intellectual disability. Mutations in TRAPPC6B can disrupt vesicle transport mechanisms leading to developmental delays and neurological symptoms. TRAPPC6B interacts with various proteins involved in these conditions like Sec23 and Sec24 which are subunits of the COPII coat. These interactions highlight the importance of TRAPPC6B in neurodevelopmental health and provide insights into possible therapeutic targets for related disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed : 16025134, PubMed : 16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).
See full target information Trafficking protein particle complex subunit 6B
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular cell 85:815-828.e10 PubMed39879985

2025

Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Carrillo Roas,Yuichi Yagita,Paul Murphy,Robert Kurzbauer,Tim Clausen,Eszter Zavodszky,Ramanujan S Hegde
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com