JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB238156

Anti-TRIM37/MUL antibody

Be the first to review this product! 리뷰 제출

|

(3 제품이 사용된 논문 )

Rabbit Polyclonal TRIM37/MUL antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM37 aa 300 to C-terminus.

대체 명칭 보기

KIAA0898, MUL, POB1, TRIM37, E3 ubiquitin-protein ligase TRIM37, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-TRIM37/MUL antibody (AB238156)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TRIM37/MUL antibody (AB238156)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for TRIM37/MUL (Green) using ab238156 at a 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM37/MUL antibody (AB238156)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM37/MUL antibody (AB238156)

Paraffin-embedded human rectum tissue stained for TRIM37/MUL with ab238156 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TRIM37 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94972

style
left-column

대체품

Primary Antibodies

AB264189

Anti-TRIM37/MUL antibody

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264189)

  • 0
  • 0
Primary Antibodies

AB264190

Anti-TRIM37/MUL antibody

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264190)

  • 0
  • 0

보완 제품

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB126758

Anti-TRAF2 antibody [EPR6048]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-TRAF2 antibody [EPR6048] (AB126758)

  • 0
  • 0
Primary Antibodies

AB134047

Anti-VCAM1 antibody [EPR5047]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-VCAM1 antibody [EPR5047] (AB134047)

  • 5
  • 17
Primary Antibodies

AB133462

Anti-IKB alpha (phospho S36) antibody [EPR6235(2)]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-IKB alpha (phospho S36) antibody [EPR6235(2)] (AB133462)

  • 4
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRIM37 also known as MUL is an E3 ubiquitin-protein ligase with a molecular mass of approximately 130 kDa. This protein plays a role in the ubiquitination process which involves labeling proteins for degradation by the proteasome. TRIM37 is widely expressed in various tissues with higher levels seen in the brain liver and heart. The protein contains a RING domain which is important for its ligase activity and mediates the attachment of ubiquitin molecules to substrate proteins therefore controlling the stability and turnover of various cellular proteins.
Biological function summary

TRIM37 regulates processes that are important for cell growth and division as well as for maintaining cellular homeostasis. It functions as part of a larger complex involved in the ubiquitin-proteasome pathway which helps to control protein degradation and recycling within the cell. Through its role in ubiquitination TRIM37 modulates the levels of proteins that are critical for controlling cell cycle progression and responding to stress. Additionally TRIM37 is involved in organizing centrosomes structures that play an important role in chromosome segregation during cell division.

Pathways

TRIM37 interacts with cellular pathways controlling autophagy and the DNA damage response. It contributes to autophagy by regulating proteins that control the formation and clearance of autophagosomes such as ULK1. In the DNA damage response TRIM37 modulates repair processes by regulating the stability of proteins like FANCD2 which is involved in the repair of DNA crosslinks. This illustrates how TRIM37 fits into wider networks inside the cell and influences processes important for maintaining genome integrity.

TRIM37 mutations are linked with Mulibrey nanism a rare growth disorder characterized by multi-organ fibrosis and growth failure. Abnormal functioning of TRIM37 disrupts the regulation of cellular proteins that maintain organ size and structure. Furthermore TRIM37 may play a role in the development of some cancers including breast cancer. In this context the protein can influence cancer progression by modifying the stability of oncogenes or tumor suppressors such as p53 adding further complexity to how TRIM37 impacts disease states.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed : 15885686, PubMed : 23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed : 23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression : associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed : 25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472' : monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed : 28724525). Has anti-HIV activity (PubMed : 24317724).
See full target information TRIM37
style
left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cancer research and clinical oncology 150:294 PubMed38842683

2024

LncRNA HOXC-AS3 accelerates malignant proliferation of cervical cancer cells via stabilizing KDM5B.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Fang Hou,Zhenghua Teng,Weiwei Xia,Jie Peng

Cancer medicine 13:e7021 PubMed38562019

2024

Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Yu,Hui Ren,Tingting Liu,Xiaoyan Han,Hui Guo,Qian Ning,Yang Li,Hong Zhou,Mingwei Chen,Tinghua Hu

Andrology 12:643-654 PubMed37644905

2023

The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chengshuang Pan,Xiangbin Kong,Zhigang Wu,Qianjin Fei
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com