AB111580

Anti-TRIM41 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal TRIM41 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM41 aa 250 to C-terminus.

대체 명칭 보기

RINCK, TRIM41, E3 ubiquitin-protein ligase TRIM41, RING finger-interacting protein with C kinase, Tripartite motif-containing protein 41

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-TRIM41 antibody (AB111580)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TRIM41 antibody (AB111580)

ab111580 at 1/200 dilution staining TRIM41 in Paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image shows cells co-stained with Hoechst 33342.

Unknown

Western blot - Anti-TRIM41 antibody (AB111580)

7.5% SDS-PAGE.

All lanes:

Western blot - Anti-TRIM41 antibody (ab111580) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 72 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRIM41 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8WV44

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRIM41 also known as RING finger protein 3 functions as an E3 ubiquitin ligase with a mass of approximately 55 kDa. It interacts with the ubiquitin-proteasome system to tag specific proteins for degradation by attaching ubiquitin molecules. TRIM41 co-exists in the cytoplasm and nucleus of various cell types. This protein exhibits significant expression in tissues such as the liver heart and kidney pointing to its versatile roles in cellular environments.

Biological function summary

TRIM41 contributes to regulating protein turnover and homeostasis within cells. It forms part of a ubiquitin ligase complex which actively recognizes and degrades targeted proteins. This regulation ensures the balance of proteins involved in processes such as cell cycle progression and signal transduction. The protein interacts with other cellular mechanisms to facilitate appropriate cellular responses to stress or changes in the extracellular environment.

Pathways

The role of TRIM41 extends to influencing processes such as the NF-kB signaling pathway and the IRF3 pathway. The NF-kB pathway involves inflammation and immune response while TRIM41 may also modulate the IRF3 pathway which is essential in innate antiviral defense mechanisms. Additionally TRIM41 interacts with proteins like TRAF3 and TRAF6 playing a role in downstream signaling events essential for cellular regulation and protection against pathogens.

TRIM41 becomes particularly relevant in the context of cancer and inflammatory diseases. Abnormal TRIM41 function associates with the development of some cancers where altered protein degradation disrupts normal cell cycle regulation. Inflammatory disorders may also involve TRIM41 due to its role in pathways mediating immune responses. The protein connects with other proteins such as p53 in cancer and NF-kB components in inflammation highlighting its contributions to pathophysiological states.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

E3 ligase that plays essential roles in innate antiviral response (PubMed : 28169297, PubMed : 29760876, PubMed : 29899090, PubMed : 31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed : 28169297, PubMed : 29899090, PubMed : 31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed : 29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed : 17893151, PubMed : 33378676).

See full target information TRIM41

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 19:e0313939 PubMed39585848

2024

Validation of the biological function and prognostic significance of AURKA in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chu

Nature communications 14:7524 PubMed37980342

2023

The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.

Applications

Unspecified application

Species

Unspecified reactive species

Sourav Saha,Shar-Yin Naomi Huang,Xi Yang,Liton Kumar Saha,Yilun Sun,Prashant Khandagale,Lisa M Jenkins,Yves Pommier

Nature communications 14:1925 PubMed37024461

2023

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes.

Applications

Unspecified application

Species

Unspecified reactive species

Liton Kumar Saha,Sourav Saha,Xi Yang,Shar-Yin Naomi Huang,Yilun Sun,Ukhyun Jo,Yves Pommier

Molecular cell 81:599-613.e8 PubMed33373584

2020

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuki Kato,Sadeem Ahmad,Zixiang Zhu,Janet M Young,Xin Mu,Sehoon Park,Harmit S Malik,Sun Hur

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRIM41 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TRIM41 antibody (AB111580)

Western blot - Anti-TRIM41 antibody (AB111580)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise