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AB220287

Anti-TRIM9 antibody

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Rabbit Polyclonal TRIM9 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM9 aa 100-200.

대체 명칭 보기

KIAA0282, RNF91, TRIM9, E3 ubiquitin-protein ligase TRIM9, RING finger protein 91, RING-type E3 ubiquitin transferase TRIM9, Tripartite motif-containing protein 9

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-TRIM9 antibody (AB220287)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TRIM9 antibody (AB220287)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized RH-30 cells labeling TRIM9 with ab220287 at 4 μg/ml (green).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human TRIM9 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9C026

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보완 제품

Primary Antibodies

AB320819

Anti-UBR4/p600 antibody [EPR28593-48]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBR4/p600 antibody [EPR28593-48] (AB320819)

  • 0
  • 0
Primary Antibodies

AB134953

Anti-Ubiquitin antibody [EPR8830]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Ubiquitin antibody [EPR8830] (AB134953)

  • 4
  • 3
Primary Antibodies

AB23366

Anti-Methylated Lysine (di methyl , mono methyl ) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Methylated Lysine (di methyl , mono methyl ) antibody (AB23366)

  • 4
  • 8
Primary Antibodies

AB230815

Anti-Smad4 antibody [EPR22589-112]

RabMAb|Recombinant|KO Validated|Advanced Validation|20ul selling size

Flow Cytometry (Intracellular) - Anti-Smad4 antibody [EPR22589-112] (AB230815)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRIM9 also known as Tripartite Motif Containing 9 is an E3 ubiquitin ligase with a mass of approximately 68 kDa. This protein adds ubiquitin to substrate proteins tagging them for proteasomal degradation or altering their activity. TRIM9 contains a RING domain B-box type zinc finger and coiled-coil region typical of the TRIM family proteins. It is widely expressed in the nervous system with high levels found in the brain highlighting its significance in neural processes.
Biological function summary

The TRIM9 protein regulates axon pathfinding and synapse formation influencing neural network development. TRIM9 forms complexes with other proteins to modulate cytoskeletal dynamics affecting neuron shape and connectivity. By interacting with proteins like DCC (Deleted in Colorectal Carcinoma) TRIM9 plays a role in guiding axons during neural circuit formation. This interaction is essential for creating proper neuronal connections and ensuring functional communication within the brain.

Pathways

TRIM9 emerges as an important regulator in the Netrin-1 signaling pathway critical for axonal guidance. This pathway involves interaction with DCC a receptor for Netrin-1 influencing axonal steering decisions. Additionally TRIM9 participates in the ubiquitination pathway affecting protein stability and cellular localization that modulates various signaling cascades within neurons. By manipulating these pathways TRIM9 assists in neural development and plasticity.

Alterations in TRIM9 expression or function correlate with neurological conditions such as schizophrenia and autism spectrum disorders. Dysfunctional TRIM9-mediated pathways might disrupt neural circuit development contributing to the cognitive and social impairments associated with these disorders. Other proteins like DCC also share connections with these disorders indicating a network of interactions where TRIM9 influences disease pathology.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
See full target information TRIM9
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The FEBS journal 292:1950-1971 PubMed39871113

2025

Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

Applications

Unspecified application

Species

Unspecified reactive species

Samael Olascoaga,Mina Konigsberg,Jesús Espinal-Enríquez,Hugo Tovar,Félix Matadamas-Martínez,Jaime Pérez-Villanueva,Norma Edith López-Diazguerrero
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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