AB194004

Anti-TROVE2/SS-A antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal TROVE2/SS-A antibody. Suitable for ELISA, WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RO60 aa 1-550.

대체 명칭 보기

SSA2, TROVE2, RO60, RNA-binding protein RO60, 60 kDa SS-A/Ro ribonucleoprotein, Ro 60 kDa autoantigen, Sjoegren syndrome antigen A2, Sjoegren syndrome type A antigen, TROVE domain family member 2, 60 kDa Ro protein, 60 kDa ribonucleoprotein Ro, RoRNP, Ro60 autoantigen, SS-A

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

Immunohistochemical analysis of paraffin-embedded Human prostate tissue labeling TROVE2/SS-A with ab194004 at 1/20 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-TROVE2/SS-A antibody (AB194004)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TROVE2/SS-A antibody (AB194004)

Immunocytochemistry/ Immunofluorescence analysis of A549 cells labeling TROVE2/SS-A with ab194004 at 1/100 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling TROVE2/SS-A with ab194004 at dilution of 1/100.

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TROVE2/SS-A antibody (AB194004)

Immunocytochemistry/Immunofluorescence analysis of PC3 cells labelling TROVE2/SS-A with ab194004 at a dilution of 1/100. An Alexa Fluor^® 488-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling TROVE2/SS-A with ab194004 at 1/20 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, ICC/IF, IHC-P, ELISA

applications

Immunogen

Recombinant Fragment Protein within Human RO60 aa 1-550. The exact immunogen used to generate this antibody is proprietary information.

P10155

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

>95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TROVE2 also known as SS-A or Ro60 is a ribonucleoprotein with molecular mass approximately 60 kDa. The protein is present mainly in the cytoplasm and nucleus of eukaryotic cells. TROVE2 functions as an essential part of the Ro ribonucleoprotein complex which binds non-coding RNA to protect it from degradation. This protein plays a role in recognizing misfolded RNA molecules and assists in their correct folding or degradation ensuring RNA quality control in the cell.

Biological function summary

TROVE2 is involved in several important cellular processes. The protein often exists as part of a complex together with La protein and small Y RNAs contributing to RNA biogenesis and stability. It helps regulate the cellular stress response by acting on misfolded RNAs and interacts with various RNA molecules through specific binding mechanisms. TROVE2's role in maintaining RNA integrity suggests it has a wider impact on the stability of the transcriptome.

Pathways

The protein TROVE2 integrates into immune response and RNA quality control pathways. It associates with molecules involved in RNA surveillance like the La protein and modulates the cell's reaction to environmental stress and pathogenic challenges. TROVE2 influences the pathways connected to RNA processing and degradation therefore intersecting with networks ensuring proper cellular function and stress management.

TROVE2 shows a connection with autoimmune disorders such as Sjögren's syndrome and systemic lupus erythematosus (SLE). These diseases often feature the production of autoantibodies against TROVE2 associating it with immune dysregulation. The interplay between TROVE2 and the La protein is notable in these conditions as both participate in producing autoantibodies contributing to the pathology of these autoimmune syndromes.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed : 18056422, PubMed : 26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed : 26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed : 26382853). May play roles in cilia formation and/or maintenance (By similarity).

See full target information RO60

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:21604 PubMed40594474

2025

The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Deborah Kajewole,Ho Ning Wong,Alexander von Kriegsheim,Richard K Haynes,Jo-Anne de la Mare,Adrienne Lesley Edkins

The EMBO journal :e104948 PubMed33226137

2020

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Amelia E Ohnstad,Jose M Delgado,Brian J North,Isha Nasa,Arminja N Kettenbach,Sebastian W Schultz,Christopher J Shoemaker

Life sciences 242:117207 PubMed31863777

2019

TROVE2 strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Chen,Yuanyuan Zhao,Huang Jin,Xiaoyu Qi,Jinrong He,Juan Huang,Yu Ding,Weiqun Chen,Chuangyan Wu,Xiangchao Ding,Shanshan Chen,Hao Zhang,Yuqiang Shang,Dunfeng Du,Jiajia Zhao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TROVE2/SS-A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

Immunocytochemistry/ Immunofluorescence - Anti-TROVE2/SS-A antibody (AB194004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

Immunocytochemistry/ Immunofluorescence - Anti-TROVE2/SS-A antibody (AB194004)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TROVE2/SS-A antibody (AB194004)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise