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AB121725

Anti-TRP14 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal TRP14 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TXNDC17 aa 1-100.

대체 명칭 보기

TXNL5, TXNDC17, Thioredoxin domain-containing protein 17, 14 kDa thioredoxin-related protein, Protein 42-9-9, Thioredoxin-like protein 5, TRP14

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP14 antibody (AB121725)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRP14 antibody (AB121725)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling TRP14 with ab121725 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-TRP14 antibody (AB121725)
  • WB

Supplier Data

Western blot - Anti-TRP14 antibody (AB121725)

All lanes:

Western blot - Anti-TRP14 antibody (ab121725) at 0.4 µg/mL

All lanes:

RT4 (human urinary bladder cancer cell line) whole cell lysate

Predicted band size: 14 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TXNDC17 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9BRA2

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보완 제품

Primary Antibodies

AB124954

Anti-TXNRD1 antibody [EPNCIR129]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-TXNRD1 antibody [EPNCIR129] (AB124954)

  • 0
  • 0
Primary Antibodies

AB236621

Anti-AGPS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGPS antibody (AB236621)

  • 0
  • 0
Assay Kits

AB65349

NADP/NADPH Assay Kit

Functional Studies - NADP/NADPH Assay Kit (AB65349)

  • 4
  • 1
Assay Kits

AB239709

GSH+GSSG / GSH Assay Kit (Colorimetric)

Functional Studies - GSH+GSSG / GSH Assay Kit (Colorimetric) (AB239709)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRP14 also known as thioredoxin-related protein 14 functions as a redox-active protein. It has a molecular mass of approximately 14 kDa. Mechanically TRP14 catalyzes the reduction of disulfide bonds in proteins playing a role in maintaining cellular redox homeostasis. Its action depends on a CXXC motif in its active site which transfers electrons to disulfides. TRP14 expresses in various human tissues with notable levels in the heart and lungs.
Biological function summary

TRP14 impacts the cellular reduction-oxidation state participating in processes of cell growth and defense against oxidative stress. It does not typically form part of larger protein complexes but instead acts independently within the cell to exert its function. Through its catalytic activity TRP14 influences signaling events that dictate cellular response to harmful oxidative conditions.

Pathways

TRP14 integrates into the thioredoxin system which regulates redox-sensitive signaling pathways. These pathways involve proteins such as TRP32 and thioredoxin. The activity of TRP14 also contributes to the oxidative stress response pathway affecting the activation of downstream targets like Nrf2 a transcription factor that mediates antioxidant defense.

TRP14 shows connection to cancer and cardiovascular diseases. Its role in maintaining redox balance can influence tumor progression and cellular transformation processes in cancer. In cardiovascular diseases oxidative stress plays an important role and TRP14 through its interaction with other redox proteins like thioredoxin may modulate associated cellular damage contributing to disease pathology.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
See full target information TXNDC17
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell 182:481-496.e21 PubMed32649862

2020

A Genetic Map of the Response to DNA Damage in Human Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Michele Olivieri,Tiffany Cho,Alejandro Álvarez-Quilón,Kejiao Li,Matthew J Schellenberg,Michal Zimmermann,Nicole Hustedt,Silvia Emma Rossi,Salomé Adam,Henrique Melo,Anne Margriet Heijink,Guillermo Sastre-Moreno,Nathalie Moatti,Rachel K Szilard,Andrea McEwan,Alexanda K Ling,Almudena Serrano-Benitez,Tajinder Ubhi,Sumin Feng,Judy Pawling,Irene Delgado-Sainz,Michael W Ferguson,James W Dennis,Grant W Brown,Felipe Cortés-Ledesma,R Scott Williams,Alberto Martin,Dongyi Xu,Daniel Durocher

Oncology reports : PubMed31524236

2019

TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Xi Tan,Tian-Min Xu,Zi-Long Zhou,Xue-Jiao Lv,Jian Liu,Wen-Jing Zhang,Man-Hua Cui

Autophagy 11:225-38 PubMed25607466

2015

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Song-Fa Zhang,Xin-Yu Wang,Zhi-Qin Fu,Qiao-Hua Peng,Jian-Yang Zhang,Feng Ye,Yun-Feng Fu,Cai-Yun Zhou,Wei-Guo Lu,Xiao-Dong Cheng,Xing Xie
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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