AB272862

Anti-TRPV2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal TRPV2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRPV2.

대체 명칭 보기

VRL, TRPV2, Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, Vanilloid receptor-like protein 1, OTRPC2, VRL-1

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

Paraffin-embedded human lung tissue stained for TRPV2 using ab272862 at 10 μg/mL in immunohistochemical analysis. Antigen retrieval using EDTA based, pH 8.0 buffer, 15 minutes.

Supplier Data

Western blot - Anti-TRPV2 antibody (AB272862)

WCE : whole cell extract; ME : membrane extract.

A 5% gel was used to observe the high molecular weight protein and run until the 72 kDa marker reaches the bottom of the gel.

All lanes:

Western blot - Anti-TRPV2 antibody (ab272862) at 1/500 dilution

Lane 1:

K562 whole cell extracts at 30 µg

Lane 2:

K562 membrane extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 85.9 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human TRPV2. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5S1

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRPV2 also known as transient receptor potential cation channel subfamily V member 2 is a non-selective cation channel with a molecular mass of around 85 kDa. Known for being heat-activated TRPV2 is sensitive to temperatures above 52°C. The protein is expressed in various tissues including heart lung spleen and brain. In neuronal and non-neuronal cells TRPV2 plays a role in calcium influx responding to potential mechanical stretch stimuli and cannabinoids like cannabidiol.

Biological function summary

TRPV2 acts as a sensor within cells and is vital for regulating calcium homeostasis affecting cellular responses in many types of cells. TRPV2 is not part of any multi-subunit complex but is often found located on the cell membrane where it modulates membrane potential and intracellular signaling. This protein contributes to tracking endogenous lipids for cellular signaling pathways necessary for various biological processes like muscle contraction and immune response.

Pathways

TRPV2 engages in cellular signaling pathways that modulate physiological responses. In particular it is part of the mechanotransduction and thermal sensing pathways where it interacts with proteins such as TRPV1 TRPV3 and TRPV4. These pathways are important for interpreting and reacting to mechanical and thermal stimuli influencing processes like inflammation and pain perception.

TRPV2 modulation impacts conditions such as cardiac hypertrophy and neurodegenerative disorders. TRPV2 interacts with proteins like calmodulin and various ion channels affecting cellular calcium dynamics that can lead to pathological states. Studies indicate that TRPV2 may play a part in the pathogenesis of heart diseases providing a link between mechanical stimuli and the development of cardiac-related conditions. Additionally aberrant regulation of TRPV2 has been implicated in muscular dystrophy highlighting its role in muscular maintenance and degradation processes.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Calcium-permeable, non-selective cation channel (PubMed : 10201375). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells (By similarity).

See full target information TRPV2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The journal of headache and pain 26:47 PubMed40045241

2025

Exploring vestibulocerebellum-vestibular nuclei-spinal trigeminal nucleus causals communication and TRPV2 ion channel in a mouse model of vestibular migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Qingling Zhai,Qihui Chen,Ning Zhang,Hongyan Li,Qijun Yu,Yonghui Pan

Circulation 148:1819-1822 PubMed38011244

2023

Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility.

Applications

Unspecified application

Species

Unspecified reactive species

Ming He,Jianjie Dong,Junmao Wen,Yuqing Zhang,So Yun Han,Chen Wang,Brendan Gongol,Tong-You Wade Wei,Jian Kang,Hsi-Yuan Huang,Susan Cheng,John Y-J Shyy

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRPV2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPV2 antibody (AB272862)

Western blot - Anti-TRPV2 antibody (AB272862)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise