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AB6069

Anti-TSH beta antibody [11E4]

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(1 출판물)

Mouse Monoclonal TSH beta antibody. Suitable for sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human Thyrotropin subunit beta.

관련 conjugated 항체와 다양한 조성의 항체 (2)

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

11E4

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

sELISA

applications

Immunogen

Native Full Length Protein corresponding to Human Thyrotropin subunit beta.

P01222

Specificity

<p>This antibody specifically recognizes ß-subunit of human TSH.</p>

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대체품

Primary Antibodies

AB64378

Anti-TSH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSH antibody (AB64378)

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보완 제품

Primary Antibodies

AB92738

Anti-CGA/hCG alpha antibody [EP3373]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGA/hCG alpha antibody [EP3373] (AB92738)

  • 0
  • 0
Assay Kits

AB100533

Human hCG ELISA Kit

Sandwich ELISA - Human hCG ELISA Kit (AB100533)

  • 0
  • 0
Primary Antibodies

AB285056

Anti-LHB antibody [EPR24484-25] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-LHB antibody [EPR24484-25] - BSA and Azide free (Detector) (AB285056)

  • 0
  • 0
Primary Antibodies

AB254257

Anti-POMC antibody [EPR22534-165]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-POMC antibody [EPR22534-165] (AB254257)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

This antibody (capture) is ELISA paired with ab6070 (conjugate).
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
Purification 관련 사항
Purity is tested by electrophoresis.
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TSH beta also known as thyrotropin beta is a subunit of the thyroid-stimulating hormone (TSH). This hormone is a glycoprotein with a significant role in regulating the endocrine system. With a molecular mass of approximately 15 kDa TSH beta is one of the two subunits that together form the functional TSH. It is produced and expressed by the anterior pituitary gland. The beta subunit confers the hormone its specificity by interacting with the TSH receptor on thyroid cells.
Biological function summary

Thyrotropin beta ensures the thyroid gland functions properly by stimulating it to release thyroxine (T4) and triiodothyronine (T3). These thyroid hormones are essential for regulating metabolism in the body. TSH beta as a part of the TSH complex must combine with the alpha subunit to exhibit full biological activity. The production and secretion of TSH are tightly controlled by the hypothalamus-pituitary-thyroid axis which adjusts TSH levels based on the body's hormone requirements.

Pathways

TSH beta has a prominent role in the hypothalamus-pituitary-thyroid axis which is fundamental in thyroid hormone regulation. This pathway involves TRH (thyrotropin-releasing hormone) from the hypothalamus which stimulates the anterior pituitary to secrete TSH. In turn TSH interacts with its receptor on the thyroid gland promoting thyroid hormone synthesis. The pathway includes feedback mechanisms where increasing levels of T3 and T4 inhibit both TRH and TSH release maintaining homeostasis.

TSH beta is linked to conditions like hyperthyroidism and hypothyroidism which result from imbalances in thyroid hormone levels. In hyperthyroidism excess production of T3 and T4 occurs often due to TSH receptor overstimulation while in hypothyroidism inadequate production might arise from insufficient TSH levels leading to decreased thyroid hormone output. Disorders with TSH beta involvement may also relate to antibodies in conditions like Graves' disease where autoantibodies target the TSH receptor causing thyroid dysfunction.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Indispensable for the control of thyroid structure and metabolism.
See full target information Thyrotropin subunit beta

대체 명칭 보기

Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, Thyrotropin beta chain, TSH-B, TSH-beta, TSHB, TSHB, CHNG4, Thyrotropin beta subunit, Thyroid stimulating hormone beta subunit, Thyroid stimulating hormone, beta precursor
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in pharmacology 9:221 PubMed29615904

2018

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Qatato,Joanna Szumska,Vladislav Skripnik,Eddy Rijntjes,Josef Köhrle,Klaudia Brix
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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