AB155959

Anti-TSH beta antibody [EPR8197]

RabMAb
Recombinant
각 태그의 뜻

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Rabbit Recombinant Monoclonal TSH beta antibody. Suitable for WB and reacts with Rabbit, Recombinant fragment - Human samples. Cited in 1 publication.

대체 명칭 보기

Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, Thyrotropin beta chain, TSH-B, TSH-beta, TSHB, TSHB, CHNG4, Thyrotropin beta subunit, Thyroid stimulating hormone beta subunit, Thyroid stimulating hormone, beta precursor

2 이미지

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Western blot - Anti-TSH beta antibody [EPR8197] (AB155959)

All lanes:

Western blot - Anti-TSH beta antibody [EPR8197] (ab155959) at 1/1000 dilution

All lanes:

Human recombinant TSH alpha/beta protein at 0.01 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 16 kDa

false

Unknown

Western blot - Anti-TSH beta antibody [EPR8197] (AB155959)

All lanes:

Western blot - Anti-TSH beta antibody [EPR8197] (ab155959) at 1/1000 dilution

All lanes:

Rabbit pituitary tissue lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 16 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8197

Isotype

IgG

Carrier free

Reacts with

Human, Rabbit

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Recombinant fragment - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" } } }

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제품 세부 정보

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TSH beta also known as thyrotropin beta is a subunit of the thyroid-stimulating hormone (TSH). This hormone is a glycoprotein with a significant role in regulating the endocrine system. With a molecular mass of approximately 15 kDa TSH beta is one of the two subunits that together form the functional TSH. It is produced and expressed by the anterior pituitary gland. The beta subunit confers the hormone its specificity by interacting with the TSH receptor on thyroid cells.

Biological function summary

Thyrotropin beta ensures the thyroid gland functions properly by stimulating it to release thyroxine (T4) and triiodothyronine (T3). These thyroid hormones are essential for regulating metabolism in the body. TSH beta as a part of the TSH complex must combine with the alpha subunit to exhibit full biological activity. The production and secretion of TSH are tightly controlled by the hypothalamus-pituitary-thyroid axis which adjusts TSH levels based on the body's hormone requirements.

Pathways

TSH beta has a prominent role in the hypothalamus-pituitary-thyroid axis which is fundamental in thyroid hormone regulation. This pathway involves TRH (thyrotropin-releasing hormone) from the hypothalamus which stimulates the anterior pituitary to secrete TSH. In turn TSH interacts with its receptor on the thyroid gland promoting thyroid hormone synthesis. The pathway includes feedback mechanisms where increasing levels of T3 and T4 inhibit both TRH and TSH release maintaining homeostasis.

TSH beta is linked to conditions like hyperthyroidism and hypothyroidism which result from imbalances in thyroid hormone levels. In hyperthyroidism excess production of T3 and T4 occurs often due to TSH receptor overstimulation while in hypothyroidism inadequate production might arise from insufficient TSH levels leading to decreased thyroid hormone output. Disorders with TSH beta involvement may also relate to antibodies in conditions like Graves' disease where autoantibodies target the TSH receptor causing thyroid dysfunction.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Indispensable for the control of thyroid structure and metabolism.

See full target information Thyrotropin subunit beta

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports. Medicine 4:100934 PubMed36754052

2023

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.

Applications

Unspecified application

Species

Unspecified reactive species

Qilin Zhang,Boyuan Yao,Xin Long,Zhengyuan Chen,Min He,Yue Wu,Nidan Qiao,Zengyi Ma,Zhao Ye,Yichao Zhang,Shun Yao,Ye Wang,Haixia Cheng,Hong Chen,Hongying Ye,Yongfei Wang,Yimin Li,Jianhua Chen,Zhaoyun Zhang,Fan Guo,Yao Zhao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TSH beta antibody [EPR8197]

Western blot - Anti-TSH beta antibody [EPR8197] (AB155959)

Western blot - Anti-TSH beta antibody [EPR8197] (AB155959)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Assay Kits

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise