AB133366

Anti-Tspan-13 antibody

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Rabbit Polyclonal Tspan-13 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TSPAN13.

대체 명칭 보기

NET6, TM4SF13, UNQ260/PRO296, TSPAN13, Tetraspanin-13, Tspan-13, Tetraspan NET-6, Transmembrane 4 superfamily member 13

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366)

ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human stomach tissue by Immunohistochemistry.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366)

ab133366, at 10 µg/ml, staining Tspan-13 in Formalin-fixed, Paraffin-embedded Human prostate tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TSPAN13. The exact immunogen used to generate this antibody is proprietary information.

O95857

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Platypus": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.01% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-80°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Tspan-13 also known as Tetraspanin 13 is a member of the tetraspanin family which are small proteins characterized by four transmembrane domains. Tspan-13 has a molecular weight of around 26 kDa and consists of a short cytoplasmic N-terminal domain four hydrophobic transmembrane domains one small and one large extracellular loop and a cytoplasmic C-terminal tail. The large extracellular loop contains conserved CCG motifs typical of tetraspanins. Tspan-13 is expressed in various tissues including the immune system such as lymphoid organs and neural tissues suggesting diverse roles throughout the body.

Biological function summary

Tspan-13 influences cell development and immune response through its role in cellular signal transduction. This protein is not just a structural component; it participates in forming tetraspanin-enriched microdomains which facilitates interactions between other proteins such as integrins and growth factor receptors. Within these microdomains Tspan-13 can modulate cell adhesion migration and proliferation which are essential processes for immune function and tissue repair.

Pathways

Studies show Tspan-13 as being involved in the integrin signaling pathway and the epidermal growth factor receptor (EGFR) signaling pathway. These pathways are significant for cellular communication and adaptation to environmental changes. In the integrin signaling pathway Tspan-13 interacts with integrin β1 modulating cell adhesion and mobility. Within the EGFR pathway Tspan-13 impacts cell proliferation and survival. Both pathways highlight Tspan-13’s role in orchestrating key cellular functions that ensure tissue homeostasis.

Research links Tspan-13 to cancer and immune-related diseases. In cancer Tspan-13 expression influences tumor progression through its involvement in cell adhesion and migration affecting metastasis. Additionally irregularities in Tspan-13 interactions with integrins may contribute to autoimmune conditions where immune cells improperly attack healthy tissue. Understanding these associations can aid in developing therapeutic strategies targeting Tspan-13 to control disease progression.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information TSPAN13

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncotarget 8:70854-70864 PubMed29050326

2017

Different effection of p.1125Val>Ala and rs11954856 in APC on Wnt signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Fei-Feng Li,Zhi-Xun Zhao,Peng Yan,Song Wang,Zheng Liu,Qiong Zhang,Xiao-Ning Zhang,Chang-Hao Sun,Xi-Shan Wang,Gui-Yu Wang,Shu-Lin Liu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tspan-13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tspan-13 antibody (AB133366)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise