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AB189962

Anti-TSPY1/TSPY antibody - C-terminal

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Rabbit Polyclonal TSPY1/TSPY antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TSPY1.

대체 명칭 보기

TSPY, TSPY1, Testis-specific Y-encoded protein 1, Cancer/testis antigen 78, CT78

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling TSPY1/TSPY with ab189962 at 5μg/ml.

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)
  • WB

Supplier Data

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (AB189962)

Lane 1:

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TSPY1/TSPY antibody - C-terminal (ab189962) at 1 µg/mL

All lanes:

A20 cell lysate

Predicted band size: 35 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human TSPY1. The exact immunogen used to generate this antibody is proprietary information.

Q01534

Specificity

At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1L (Isoform 2).

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보완 제품

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR4 antibody [UMB2] (AB124824)

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Primary Antibodies

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Primary Antibodies

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TSPY1 also known as Testis-Specific Protein Y-Encoded is a Y-linked gene with a protein product weighing approximately 38 kDa. This protein is mainly expressed in male germ cells found in the testes. TSPY1 functions as a nucleosome assembly factor which implicates its role in chromatin remodeling and regulation of transcription. It shows specific expression in the testis indicating its role in spermatogenesis and fertility processes.
Biological function summary

TSPY1 influences cellular division and differentiation within the testes. As part of the DNA-binding protein family it associates with other proteins to impact germ cell progression. TSPY1 plays a role in the maintenance and proliferation of spermatogonial cells which are precursors to sperm cells. Its involvement here links it closely with cell cycle regulation and meiotic processes.

Pathways

TSPY1 associates with regulatory processes important for the maintenance of spermatogonial stem cells. It participates in pathways including the Wnt signaling pathway which is essential for cell growth and differentiation. TSPY1 interacts with proteins such as Cyclin B influencing the G2/M transition during cell division. This interaction highlights its importance in ensuring proper cell cycle progression and indicates its pivotal role in reproductive biology.

TSPY1 has associations with testicular germ cell tumors and infertility. Abnormal expression of TSPY1 is found in a significant number of testicular cancer cases highlighting its oncogenic potential. It connects with oncogenes such as Cyclin D2 contributing to tumor cell proliferation. Furthermore deletions or duplications of TSPY1 might relate to spermatogenic failure causing male infertility. These associations highlight the importance of TSPY1 in both normal testicular function and its relevance in pathophysiological conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be involved in sperm differentiation and proliferation.
See full target information TSPY1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging 14:2268-2286 PubMed35255005

2022

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiwu Ouyang,Lemeng Feng,Lei Yao,Jingyu Zhang,Yao Xiao,Guodong Liu,Gewen Zhang,Zhiming Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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