AB204046

Anti-TTYH1 antibody

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Rabbit Polyclonal TTYH1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein tweety homolog 1 aa 250-400.

대체 명칭 보기

Protein tweety homolog 1, hTTY1, Volume-regulated anion channel subunit TTYH1, TTYH1

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTYH1 antibody (AB204046)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTYH1 antibody (AB204046)

Immunohistochemical analysis of paraffin-embedded human cerebellum tissue labeling TTYH1 in the neuropil with ab204046 at a 1/50 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Supplier Data

Western blot - Anti-TTYH1 antibody (AB204046)

All lanes:

Western blot - Anti-TTYH1 antibody (ab204046) at 0.4 µg/mL

All lanes:

Human cerebral cortex tissue lysate

Predicted band size: 49 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Protein tweety homolog 1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q9H313

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TTYH1 also known as Tweety homolog 1 is a transmembrane protein that belongs to the Tweety protein family. It has a mass of approximately 60 kDa. TTYH1 functions as a chloride channel and shows expression notably in the central nervous system particularly in the brain. Researchers observe its presence in several cell types including neurons and glial cells. Its expression pattern suggests a role linked to neural development and function.

Biological function summary

TTYH1 participates in the regulation of ion transport across cellular membranes. This function plays a significant role in maintaining cellular homeostasis and electrical excitability. TTYH1 supports chloride ion movement which influences cell volume regulation and neural signal transduction. TTYH1 might associate with other channel proteins and complexes that contribute to membrane potential and cell signaling processes impacting neurological processes.

Pathways

TTYH1 contributes to ion homeostasis and synaptic transmission processes within neural pathways. It interacts notably with proteins involved in the chloride ion transport pathway essential for maintaining proper neuronal activity. One of these other proteins is CLCN2 a chloride channel protein. TTYH1's function aligns with its role in maintaining the ion balance necessary for synaptic activity and effective neurotransmission.

Aberrant TTYH1 activity potentially links to neurological disorders including epilepsy and glioma. The abnormal function or expression of TTYH1 may impact the balance of ions within neurons which carries implications for neural excitability and seizure susceptibility in epilepsy. Additionally its expression in glioma suggests a role in the progression or pathology of tumor growth in the central nervous system. TTYH1's link with such conditions draws attention to its potential interactions with proteins like connexin43 which is involved in cell-to-cell communication and could further influence disease dynamics.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate.. Isoform 3. Ca(2+)-independent, swelling-activated chloride channel, possibly involved in regulation of cell volume.

See full target information Protein tweety homolog 1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 11: PubMed35088712

2022

Paraxial mesoderm organoids model development of human somites.

Applications

Unspecified application

Species

Unspecified reactive species

Christoph Budjan,Shichen Liu,Adrian Ranga,Senjuti Gayen,Olivier Pourquié,Sahand Hormoz

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TTYH1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTYH1 antibody (AB204046)

Western blot - Anti-TTYH1 antibody (AB204046)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise