AB70182

Anti-TUSC2/FUS1 antibody

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(6 제품이 사용된 논문 )

Rabbit Polyclonal TUSC2/FUS1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TUSC2.

1 이미지

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Western blot - Anti-TUSC2/FUS1 antibody (AB70182)

All lanes:

Western blot - Anti-TUSC2/FUS1 antibody (ab70182) at 1/500 dilution

Lane 1:

HeLa cell extract at 5 µg

Lane 2:

HeLa cell extract at 5 µg with immunising peptide

Predicted band size: 12 kDa

Observed band size: <19 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human TUSC2. The exact immunogen used to generate this antibody is proprietary information.

O75896

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The TUSC2/FUS1 protein also known by its alternate name TUSC2 plays an essential role in cellular processes. It has a molecular mass of approximately 12 kDa and is found throughout various tissues but is predominantly expressed in the mitochondria. TUSC2 localizes to chromosomal region 3p21.3 which often undergoes deletions in lung cancer. Its expression can be lost or significantly reduced in certain cancers indicating its potential tumor-suppressive role.

Biological function summary

TUSC2 participates in several critical cellular functions and is part of a larger complex with other proteins. It influences cell proliferation apoptosis and signal transduction pathways. TUSC2 functions as a tumor suppressor helping to regulate cell growth and prevent malignant transformation. It acts in apoptosis induction and cell cycle control often by modulating reactive oxygen species (ROS) levels within cells.

Pathways

TUSC2 is instrumental in regulating several cellular pathways. It is a participant in the PI3K/Akt and MAPK pathways which are vital for cell survival growth and metabolism. TUSC2 interacts with proteins like Akt and p53 playing an important role in maintaining cellular homeostasis and preventing aberrant cell division. These interactions help TUSC2 modulate apoptosis and promote cell-cycle arrest under stressful conditions.

TUSC2 has a notable connection to cancer particularly lung cancer and mesothelioma. In these diseases TUSC2 expression often decreases due to chromosomal deletions. The protein's interaction with other tumor suppressors such as p53 and PTEN influences tumorigenesis by disrupting normal signaling pathways leading to uncontrolled cell proliferation. Restoring TUSC2 function or expression could open avenues for therapeutic interventions in cancer treatment.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

See full target information TUSC2

대체 명칭 보기

C3orf11, FUS1, LGCC, PDAP2, TUSC2, Tumor suppressor candidate 2, Fusion 1 protein, PDGFA-associated protein 2, Fus-1 protein

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer letters 531:124-135 PubMed35167936

2022

NEDD4 degrades TUSC2 to promote glioblastoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Tadas K Rimkus,Austin B Arrigo,Dongqin Zhu,Richard L Carpenter,Sherona Sirkisoon,Daniel Doheny,Angelina T Regua,Grace L Wong,Sara Manore,Calvin Wagner,Hui-Kuan Lin,Guangxu Jin,Jimmy Ruiz,Michael Chan,Waldemar Debinski,Hui-Wen Lo

Cellular and molecular neurobiology 42:2245-2256 PubMed33993369

2021

Circ-EGFR Functions as an Inhibitory Factor in the Malignant Progression of Glioma by Regulating the miR-183-5p/TUSC2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qingdong Guo,Jun Guo,Wei Liu,Shijie Hu,Xuean Hu,Qianliang Wang,Xiaofan Jiang

Scientific reports 9:12718 PubMed31481748

2019

MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.

Applications

Unspecified application

Species

Unspecified reactive species

Srikanth Nama,Manish Muhuri,Federica Di Pascale,Shan Quah,Luay Aswad,Melissa Fullwood,Prabha Sampath

BMC cancer 18:894 PubMed30219035

2018

TUSC2P suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and correlates with disease prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Fengqiong Liu,Ruijie Gong,Baochang He,Fa Chen,Zhijian Hu

PloS one 10:e0137887 PubMed26367773

2015

Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.

Applications

Species

Human

Kumiko Yamamoto,Sachio Ito,Hiroko Hanafusa,Kenji Shimizu,Mamoru Ouchida

Nature communications 5:2914 PubMed24394498

2014

The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs.

Applications

Species

Mouse

Zina Jeyapalan Rutnam,William W Du,Weining Yang,Xiangling Yang,Burton B Yang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TUSC2/FUS1 antibody

Western blot - Anti-TUSC2/FUS1 antibody (AB70182)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (6)

Product promise