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AB138267

Anti-UBR1 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal UBR1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human UBR1.

대체 명칭 보기

E3 ubiquitin-protein ligase UBR1, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human UBR1. The exact immunogen used to generate this antibody is proprietary information.

Q8IWV7

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보완 제품

Primary Antibodies

AB217069

Anti-UBR2 antibody

Immunoprecipitation - Anti-UBR2 antibody (AB217069)

  • 0
  • 0
Primary Antibodies

AB245522

Anti-NEDD4-2 antibody

Immunoprecipitation - Anti-NEDD4-2 antibody (AB245522)

  • 5
  • 1
Primary Antibodies

AB7254

Anti-Ubiquitin antibody [Ubi-1]

Western blot - Anti-Ubiquitin antibody [Ubi-1] (AB7254)

  • 4
  • 6
Primary Antibodies

AB170901

Anti-SYVN1/HRD1 antibody [EP7459]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SYVN1/HRD1 antibody [EP7459] (AB170901)

  • 3
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab138267 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

UBR1 also known as E3 ubiquitin-protein ligase UBR1 is a component of the N-end rule pathway. This protein has a mass of approximately 220 kDa and functions as an E3 ubiquitin ligase. It recognizes proteins with destabilizing N-terminal residues and facilitates their polyubiquitination marking them for proteasomal degradation. UBR1 is expressed abundantly in tissues such as the heart pancreas and brain which suggests its significant role in cellular processes across multiple organ systems.
Biological function summary

In cellular regulation and homeostasis UBR1 plays a critical role. As a part of the larger ubiquitin-proteasome system it maintains protein quality control and modulates turnover rates of key proteins which ensures normal cellular functions. Although not directly a part of a complex it interacts with other UBR family members like UBR2 under overlapping pathways which can influence the degradation of specific proteins thereby impacting various signaling cascades.

Pathways

UBR1 is an integral regulator within the proteolytic pathways particularly the N-end rule pathway and ubiquitin-mediated proteolysis. In the N-end rule pathway it cooperates closely with other components like UBR2 which together target specific substrates for degradation therefore impacting processes like cell cycle regulation and stress responses. These pathways ensure balanced protein levels influencing processes such as cell growth and apoptosis vital for maintaining cellular integrity.

UBR1 mutations or dysfunction are strongly associated with Johanson-Blizzard Syndrome and pancreatic insufficiency. Patients with these conditions often present genetic mutations that impair UBR1's normal function leading to disrupted protein degradation and developmental abnormalities. The disruptions in UBR1 function also show interactions with proteins involved in growth and development suggesting its broader role in maintaining physiological stability and highlighting its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed : 15548684, PubMed : 16311597, PubMed : 18162545, PubMed : 20835242, PubMed : 28392261). Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed : 18162545, PubMed : 20835242, PubMed : 28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed : 18162545). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed : 20835242). In contrast, it strongly binds methylated N-degrons (PubMed : 28392261). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed : 20298436).
See full target information UBR1
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 44:115434 PubMed40131931

2025

SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response.

Applications

Unspecified application

Species

Unspecified reactive species

Nurul Khalida Ibrahim,Sabine Schreek,Buesra Cinar,Anna Sophie Stasche,Su Hyun Lee,Andre Zeug,Tim Dolgner,Julia Niessen,Evgeni Ponimaskin,Halyna Shcherbata,Beate Fehlhaber,Jean-Pierre Bourquin,Beat Bornhauser,Martin Stanulla,Andreas Pich,Alejandro Gutierrez,Laura Hinze

Cancer biology & therapy 25:2408042 PubMed39341782

2024

Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Wang,Qifan Jia,Jingyao Sun,Sen Wu,Li Wei,Wenjian Yao

Journal of cellular biochemistry 121:804-815 PubMed31407360

2019

N-end rule pathway inhibitor sensitizes cancer cells to antineoplastic agents by regulating XIAP and RAD21 protein expression.

Applications

Unspecified application

Species

Unspecified reactive species

Subrata K Pore,Anirban Ganguly,Samaresh Sau,Sudhakar Godeshala,Anantha K Kanugula,Ramesh Ummanni,Srigiridhar Kotamraju,Rajkumar Banerjee
제품이 사용된 논문 모두 보기
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Product promise

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