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AB240932

Anti-Uroplakin III antibody [SP73] - BSA and Azide free

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(1 출판물)

Rabbit Recombinant Monoclonal Uroplakin III antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

UPK3, UPK3A, Uroplakin-3a, UP3a, Uroplakin III, UPIII

관련 conjugated 항체와 다양한 조성의 항체 (8)

  • Unconjugated

    Anti-Uroplakin III antibody [SP73]

  • 660 APC

    APC Anti-Uroplakin III antibody [SP73]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Uroplakin III antibody [SP73]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Uroplakin III antibody [SP73]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Uroplakin III antibody [SP73]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Uroplakin III antibody [SP73]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Uroplakin III antibody [SP73]

  • 578 PE

    PE Anti-Uroplakin III antibody [SP73]

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

SP73

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB187299

Anti-Uroplakin III antibody - C-terminal

Western blot - Anti-Uroplakin III antibody - C-terminal (AB187299)

  • 0
  • 0
Primary Antibodies

AB78196

Anti-Uroplakin III antibody [SFI-1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody [SFI-1] (AB78196)

  • 4
  • 8
Primary Antibodies

AB231576

Anti-Uroplakin III antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody (AB231576)

  • 5
  • 1
Primary Antibodies

AB187646

Anti-Uroplakin III antibody [EPR14420]

RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody [EPR14420] (AB187646)

  • 0
  • 0
Primary Antibodies

AB239006

Anti-Uroplakin III antibody [EPR14420] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody [EPR14420] - BSA and Azide free (AB239006)

  • 0
  • 0
Primary Antibodies

AB82173

Anti-Uroplakin III antibody

Western blot - Anti-Uroplakin III antibody (AB82173)

  • 0
  • 0
Primary Antibodies

AB150409

Anti-Uroplakin III antibody [EPR3612(2)]

RabMAb|Recombinant

Western blot - Anti-Uroplakin III antibody [EPR3612(2)] (AB150409)

  • 0
  • 1

보완 제품

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB16662

Anti-ErbB2 / HER2 antibody [SP3]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB2 / HER2 antibody [SP3] (AB16662)

  • 5
  • 2
Primary Antibodies

AB237709

Anti-CD8 alpha antibody [CAL66]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD8 alpha antibody [CAL66] (AB237709)

  • 5
  • 2
Primary Antibodies

AB16663

Anti-Cyclin D1 antibody [SP4]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials

Western blot - Anti-Cyclin D1 antibody [SP4] (AB16663)

  • 4
  • 23
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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제품 세부 정보

ab240932 is the carrier-free version of ab93721.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
Purification 관련 사항
Purified from TCS by protein A/G.
보관 버퍼
pH: 7.2 - 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Do Not Freeze
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Uroplakin III also known as UPK3 or UPIII is a transmembrane protein with a molecular weight of around 47 kDa. It is specifically expressed in the urothelium which lines the urinary tract including the bladder ureter and renal pelvis. Uroplakin III plays a structural role by contributing to the formation of the asymmetric unit membrane important for the stability and impermeability of the urothelial barrier.
Biological function summary

Uroplakin III takes part in the formation of the uroplakin complex which includes UPIa UPIb and UPII. It interacts with these proteins to form the urothelial plaques that are essential in maintaining the integrity of the urothelial surface. These plaques prevent urine from permeating back into the underlying tissues ensuring proper urinary function. Uroplakin III also participates in signal transduction mechanisms that may regulate cell proliferation within the urothelial lining.

Pathways

Uroplakin III works within the context of membrane assembly and bladder epithelium differentiation. It interacts with proteins like other uroplakins and cytoskeletal components to mediate the formation of apical urothelial plaques. The protein contributes to signaling pathways that involve cellular differentiation and proliferation ensuring the proper function and renewal of urothelial tissue.

Uroplakin III shows significant relevance in the context of bladder carcinoma and interstitial cystitis. Bladder carcinoma often exhibits altered expression of Uroplakin III suggesting its potential role as a diagnostic marker. In interstitial cystitis changes in Uroplakin III distribution might contribute to the compromised barrier function. Its altered interaction with proteins like uroplakin II can emphasize the link between these structural changes and disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
See full target information UPK3A
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology letters 21:486 PubMed33968202

2021

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR-1244/MAP3K2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodong Li,Baihetiya Azhati,Wenguang Wang,Mulati Rexiati,Chen Xing,Yujie Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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