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AB240543

Anti-USP31 antibody

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(2 제품이 사용된 논문 )

Goat Polyclonal USP31 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human USP31 aa 1250 to C-terminus.

대체 명칭 보기

KIAA1203, USP31, Ubiquitin carboxyl-terminal hydrolase 31, Deubiquitinating enzyme 31, Ubiquitin thioesterase 31, Ubiquitin-specific-processing protease 31

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human USP31 aa 1250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q70CQ4

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보완 제품

Proteins & Peptides

AB163562

Recombinant Human USP31 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human USP31 protein (GST tag N-Terminus) (AB163562)

  • 0
  • 0
Primary Antibodies

AB178876

Anti-MEK1 + MEK2 antibody [EPR16667]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEK1 + MEK2 antibody [EPR16667] (AB178876)

  • 5
  • 1
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3-5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

USP31 also known as Ubiquitin Specific Peptidase 31 belongs to the family of deubiquitinating enzymes. It plays a role in regulating protein homeostasis by removing ubiquitin from target proteins. USP31 has a molecular mass of approximately 140 kDa. It is expressed across various tissues but shows higher levels in the liver brain and immune cells. This expression pattern suggests its involvement in important cellular processes within these tissues.
Biological function summary

USP31 contributes to the regulation of NF-kB signaling pathways an important process in inflammation and immune responses. It acts by deubiquitinating and stabilizing specific substrates affecting the nuclear translocation of NF-kB. USP31 does not solely act but works as part of a larger complex within the cell interacting with other proteins to ensure precise regulation of signaling events. This action impacts the cell’s response to stress and pro-inflammatory signals.

Pathways

USP31 actively participates in the NF-kB pathway and the response to viral infections. In the context of the NF-kB pathway it closely interacts with proteins such as IKKα and IKKβ which are pivotal in NF-kB activation and can influence inflammatory outcomes. In relation to the antiviral response USP31 modulates pathways involving type I interferon production linking it with proteins like IRF3 and IRF7 critical for mounting an effective immune response against viral threats.

Dysfunction or altered expression of USP31 associates with conditions like chronic inflammation and certain cancers. In inflammatory diseases USP31’s erroneous activity amplifies or diminishes NF-kB signaling connecting it with inflammatory cytokines and proteins like TNF-α and IL-6. In cancer abnormalities in USP31 regulation contribute to unchecked cell growth and survival signals potentially working in tandem with proteins such as p53 and MDM2 which are central to the cellular stress response and tumor suppression mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2.. (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein.
See full target information USP31
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39:e70352 PubMed39874047

2025

Segment specific loss of NFAT5 function in the kidneys is sufficient to induce a global kidney injury like phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Kristina Engel,Vera Anna Kulow,Dmitry Chernyakov,Edith Willscher,Michael Fähling,Bayram Edemir

Biomolecules & biomedicine 23:426-436 PubMed36508192

2022

Systemic analysis of the expression and prognostic significance of USP31 in endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhen Huang,Peng Jiang,Yuting Chen,Jinyu Wang,Rui Yuan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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