Anti-USP36 antibody

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Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed : 19208757, PubMed : 22902402, PubMed : 29273634). Required for cell and organism viability (PubMed : 19208757, PubMed : 22902402, PubMed : 29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed : 19208757, PubMed : 22902402, PubMed : 29273634, PubMed : 36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed : 29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome : acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed : 25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed : 25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed : 27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed : 21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed : 22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed : 35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed : 36912080). Binds to pre-rRNAs (PubMed : 36912080).