Anti-USP46 antibody [CL0364]

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Biological function summary

USP46 modulates the ubiquitin-proteasome system by removing ubiquitin from substrate proteins which impacts their degradation or activity. It exists as part of a larger protein complex interacting with proteins such as WDR20 which enhance its activity. This interaction allows USP46 to regulate protein homeostasis within neurons and other cells. In the nervous system its activity supports synaptic function and plasticity contributing to effective neural communication and cognitive processes.

Pathways

USP46 mainly acts within the ubiquitin-proteasome pathway an essential mechanism for protein degradation and regulation. It interacts with proteins like UBE3A and UCH-L1 which are important for maintaining protein balance and cellular stress responses. Another important pathway involving USP46 is the neural plasticity and signaling pathway where it helps in regulating the degradation of synaptic proteins contributing to learning and memory.