AB244363

Anti-Utrophin antibody

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Rabbit Polyclonal Utrophin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UTRN aa 1350 to C-terminus.

대체 명칭 보기

DMDL, DRP1, UTRN, Utrophin, Dystrophin-related protein 1, DRP-1

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human stomach tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human prostate tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Formalin-fixed, paraffin-embedded human liver tissue stained for Utrophin with ab244363 at a 1/50 dilution in immunohistochemical analysis.

No membranous positivity in hepatocytes as expected.

Immunocytochemistry/ Immunofluorescence - Anti-Utrophin antibody (AB244363)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Utrophin antibody (AB244363)

PFA fixed, Triton X-100 permeabilized U-251 MG (Human brain glioma cell line) cells labeling Utrophin using ab244363 at 4 μg/ml (green) in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human UTRN aa 1350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P46939

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Utrophin also known as dystrophin-related protein plays a mechanical role in muscle tissue by connecting the cytoskeleton to the extracellular matrix. It has a molecular mass of about 395 kDa. This protein localizes mainly at the neuromuscular junctions and myotendinous junctions. Utrophin shows expression in various tissues but is more common in fetal and regenerating muscle fibers suggesting its function is important during muscle development and repair.

Biological function summary

Utrophin maintains muscle integrity and stability by forming part of the dystrophin-associated glycoprotein complex. This complex acts as a scaffold needed for structural support in muscle cells aiding in proper muscle function and repair. Utrophin substitutes dystrophin especially when dystrophin is absent or defective in muscles making it an important player in compensatory mechanisms.

Pathways

Utrophin actively participates in muscle signaling and structural integrity processes. It is important within the Jak-STAT signaling pathway and the pathways involved in muscle dystrophy. Through these pathways utrophin interacts with proteins like dystroglycans and sarcoglycans which help support its role in maintaining the structural framework of muscle tissues.

The absence or abnormal expression of utrophin is linked to muscular dystrophies especially Duchenne Muscular Dystrophy (DMD). Utrophin is being explored as a potential therapeutic target to compensate for the lack of dystrophin in this context. Enhanced expression of utrophin may alleviate muscle degeneration seen in DMD by interacting with proteins normally associated with dystrophin in healthy muscle like syntrophins and sarcospan.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May play a role in anchoring the cytoskeleton to the plasma membrane.

See full target information UTRN

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine (Cambridge, Mass.) 31:278 PubMed40819077

2025

Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Lian,Jiayi Li,Shihui Tang,Ting Li,Jinping Li

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Utrophin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Utrophin antibody (AB244363)

Immunocytochemistry/ Immunofluorescence - Anti-Utrophin antibody (AB244363)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise