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AB244398

Anti-VANGL1 antibody

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Rabbit Polyclonal VANGL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human VANGL1 aa 1-150.

대체 명칭 보기

STB2, VANGL1, Vang-like protein 1, Loop-tail protein 2 homolog, Strabismus 2, Van Gogh-like protein 1, LPP2

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-VANGL1 antibody (AB244398)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-VANGL1 antibody (AB244398)

PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for VANGL1 (green) using ab244398 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human VANGL1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8TAA9

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대체품

Primary Antibodies

AB242311

Anti-VANGL1 antibody [CL0241]

Immunocytochemistry/ Immunofluorescence - Anti-VANGL1 antibody [CL0241] (AB242311)

  • 0
  • 0
Primary Antibodies

AB176575

Anti-VANGL1 antibody [EPR12415]

RabMAb|Recombinant

Western blot - Anti-VANGL1 antibody [EPR12415] (AB176575)

  • 4
  • 1

보완 제품

Primary Antibodies

AB150545

Anti-Frizzled 6 antibody - N-terminal

Immunocytochemistry - Anti-Frizzled 6 antibody - N-terminal (AB150545)

  • 0
  • 0
Primary Antibodies

AB5103

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

  • 4
  • 28
Primary Antibodies

AB124933

Anti-Dishevelled 2 (phospho S143) antibody [EPNCIR145]

RabMAb|Recombinant

Western blot - Anti-Dishevelled 2 (phospho S143) antibody [EPNCIR145] (AB124933)

  • 0
  • 0
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

VANGL1 also known as Van Gogh-Like Protein 1 plays a mechanical role in cell biology related to polarized cell movement and development. It has a molecular mass of approximately 65 kDa. VANGL1 is expressed in various tissues with significant presence in the kidneys lungs and brain. It localizes to the cell membrane where it participates in the establishment of cell polarity.
Biological function summary

VANGL1 is an essential component of the planar cell polarity (PCP) signaling pathway where it guides cell orientation and tissue architecture. This protein is part of a larger protein complex that includes Prickle and Fluorescent in situ hybridization (Fzd) receptors. VANGL1's interactions in this complex facilitate cellular orientation playing a central role in the morphogenesis of epithelial tissues.

Pathways

Researchers have linked VANGL1 to the Wnt/PCP and non-canonical Wnt signaling pathways. These pathways are important for the regulation of cytoskeletal dynamics and cell motility. VANGL1 interacts with proteins such as the Dishevelled protein family and CELSR1 which are important for signal transduction within these pathways. Proper VANGL1 function ensures accurate cell positioning and movement which are key for embryonic development and organogenesis.

VANGL1 has been implicated in conditions such as neural tube defects and colorectal cancer. In neural tube defects mutations in VANGL1 may disrupt normal cell polarity processes interfering with neural tube closure. Similarly aberrant VANGL1 expression and its interactions with other proteins like KIF7 in the PCP pathway have been associated with the progression of colorectal cancer. Understanding VANGL1's interactions and mutations can provide insights into mechanisms underlying these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information VANGL1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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