AB96085

Anti-VBP-1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal VBP-1 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VBP1 aa 1-150.

2 이미지

Unknown

Western blot - Anti-VBP-1 antibody (AB96085)

12% SDS-PAGE

All lanes:

Western blot - Anti-VBP-1 antibody (ab96085) at 1/1000 dilution

All lanes:

A549 whole cell lysate at 30 µg

Predicted band size: 23 kDa

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Supplier Data

Western blot - Anti-VBP-1 antibody (AB96085)

Samples were separated by 12% SDS-PAGE.

All lanes:

Western blot - Anti-VBP-1 antibody (ab96085) at 1/1000 dilution

All lanes:

Mouse brain tissue lysate at 50 µg

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human VBP1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

P61758

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

VBP-1 also known as Von Hippel-Lindau binding protein 1 or prefoldin subunit 3 is a small protein with a molecular mass of approximately 23 kDa. It is expressed in various tissues including the brain heart and skeletal muscle. Mechanically VBP-1 functions as a molecular chaperone facilitating the proper folding of newly synthesized proteins and preventing the aggregation of misfolded proteins. It interacts with different molecular partners to exert its chaperoning activity.

Biological function summary

VBP-1 plays an important role in protein homeostasis particularly by forming part of the prefoldin complex. This complex works alongside the cytosolic chaperonin complex helping with the proper folding of cytoskeletal proteins such as actin and tubulin. By stabilizing these newly synthesized proteins VBP-1 supports cellular structures and intracellular transport systems reflecting its involvement in maintaining cellular integrity.

Pathways

VBP-1 plays a role in the ubiquitin-proteasome pathway and the cellular stress response pathway. In the ubiquitin-proteasome pathway it partners with proteins like HSP70 to target damaged proteins for degradation. In response to cellular stress VBP-1 helps in protein stabilization to prevent harmful aggregation correlating with HSP90 in maintaining cellular homeostasis during stress conditions.

VBP-1 has connections with neurodegenerative diseases such as Alzheimer's disease due to its role in protein folding and aggregation. Misregulation of VBP-1 can lead to the accumulation of neurotoxic protein aggregates. Additionally VBP-1 has been associated with cancer particularly through its interaction with pVHL (von Hippel-Lindau protein). Dysregulation in VBP-1 activity can result in the disruption of the ubiquitin-proteasome system leading to uncontrolled cell growth and cancer development.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

See full target information VBP1

대체 명칭 보기

PFDN3, VBP1, Prefoldin subunit 3, HIBBJ46, von Hippel-Lindau-binding protein 1, VBP-1, VHL-binding protein 1

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The European journal of neuroscience 59:2102-2117 PubMed38279611

2024

Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Afra Aabdien,Laura Sichlinger,Zoe Borgel,Madeleine R Jones,Iain A Waston,Nicholas J F Gatford,Pooja Raval,Lloyd Tanangonan,Timothy R Powell,Rodrigo R R Duarte,Deepak P Srivastava

Cancers 12: PubMed32344577

2020

Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xenia Peñate,Juan Manuel Praena-Fernández,Pedro Romero Pareja,María Del Valle Enguix-Riego,Laura Payán-Bravo,Begoña Vieites,Lourdes Gomez-Izquierdo,Javier Jaen Olasolo,Eleonor Rivin Del Campo,Jose Carlos Reyes,Sebastián Chávez,Jose Luis Lopez Guerra

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-VBP-1 antibody

Western blot - Anti-VBP-1 antibody (AB96085)

Western blot - Anti-VBP-1 antibody (AB96085)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (2)

Product promise