AB231670

Anti-VE-PTP antibody

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Rabbit Polyclonal protein-tyrosine-phosphatase antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication.

대체 명칭 보기

Ptprb

7 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat liver tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat skeletal muscle tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat heart tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat brain tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Paraffin-embedded rat spinal cord tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-VE-PTP antibody (AB231670)

All lanes:

Western blot - Anti-VE-PTP antibody (ab231670) at 2 µg/mL

All lanes:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 224 kDa

false

Supplier Data

Western blot - Anti-VE-PTP antibody (AB231670)

All lanes:

Western blot - Anti-VE-PTP antibody (ab231670) at 2 µg/mL

All lanes:

Recombiant rat VE-PTP protein

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 224 kDa,42 kDa,57 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P, WB

applications

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

ab231670 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

VE-PTP also known as vascular endothelial protein tyrosine phosphatase is an enzyme with a mass of approximately 300 kDa. This protein is part of the receptor-type protein tyrosine phosphatase family and it mainly localizes at endothelial cell junctions. VE-PTP plays an important role in maintaining endothelial cell permeability by dephosphorylating specific tyrosine residues on target proteins such as the VE-cadherin complex. Its expression confines mostly to vascular endothelial cells where it is involved in processes affecting vascular stability and signaling.

Biological function summary

The function of this protein extends to its involvement in the modulation of cell adhesion through its interaction with adherens junctions complexes. VE-PTP associates with complexes like VE-cadherin and plakoglobin to regulate cell–cell junctions influencing the integrity and permeability of the vascular endothelium. This activity is important in processes such as angiogenesis and the maintenance of vascular barrier function making it a significant player in vascular biology.

Pathways

The participation of VE-PTP is notably within the angiogenesis and vascular barrier regulation pathways. The protein governs these pathways by regulating signals through interactions with proteins like VE-cadherin and VEGFR2 which are essential in vascular development and response to growth factors. Its phosphatase activity moderates the phosphorylation state of these key partners thereby influencing the downstream signaling events vital for endothelial function and vascular homeostasis.

The function of VE-PTP associates with pathological conditions such as cancer and cardiovascular diseases. In cancer its role in angiogenesis can contribute to tumor vascularization impacting tumor growth and metastasis. Meanwhile in cardiovascular diseases its influence on endothelial permeability can affect atherosclerotic plaque stability and contribute to vascular complications. Interacting proteins such as VEGFR2 are also implicated in these disorders linking VE-PTP to these disease pathways through their regulatory relationships in endothelial dynamics.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information protein-tyrosine-phosphatase

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature metabolism 3:1202-1216 PubMed34552271

2021

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Aliluev,Sophie Tritschler,Michael Sterr,Lena Oppenländer,Julia Hinterdobler,Tobias Greisle,Martin Irmler,Johannes Beckers,Na Sun,Axel Walch,Kerstin Stemmer,Alida Kindt,Jan Krumsiek,Matthias H Tschöp,Malte D Luecken,Fabian J Theis,Heiko Lickert,Anika Böttcher

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-VE-PTP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VE-PTP antibody (AB231670)

Western blot - Anti-VE-PTP antibody (AB231670)

Western blot - Anti-VE-PTP antibody (AB231670)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise