Anti-VGLUT2 antibody - C-terminal

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Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed : 11432869, PubMed : 17108179, PubMed : 25433636, PubMed : 33440152). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed : 11432869, PubMed : 17108179). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed : 11432869). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed : 25433636). The vesicular H(+)/H(+) antiport activity is electroneutral (PubMed : 25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed : 33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed : 33440152). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (PubMed : 30936473). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity).

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Dnpi, Vglut2, Slc17a6, Vesicular glutamate transporter 2, VGluT2, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 6